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Review
. 2020 Dec 1;39(4):307-312.
doi: 10.36185/2532-1900-034. eCollection 2020 Dec.

The impact of SARS-CoV-2 on skeletal muscles

Maria Rita De Giorgio  1   2 , Stefania Di Noia  2   3 , Cinzia Morciano  1   2 , Diana Conte  4   5
Affiliations
Review

The impact of SARS-CoV-2 on skeletal muscles

Maria Rita De Giorgio et al. Acta Myol. .

Abstract

In 2019-2020, the SARS-CoV-2 pandemic has shocked the world and most health care systems, and a "second wave" of the viral spread is ongoing in Europe and in Italy too. While, at the initial outbreak, the treatment of patients had focused on the respiratory symptoms, many diverse clinical manifestations of the disease have to date been reported. However, the complete course of the disease has not yet been fully clarified. In particular, several reports from the real-world clinical practice have highlighted the noxious effects of SARS-CoV-2 on skeletal muscles. In this brief review, we summarized the main current findings about muscular and neuromuscular damages that may be triggered by the virus or by the drugs used to treat COVID-19. Moreover, we underlined the need of attentive care and vigilance for patients with neuro-muscular disorders, who may be particularly susceptible to infection and at increased risk for severe COVID-19.

Keywords: COVID-19; SARS-CoV-2; skeletal muscles.

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Conflict of interest statement

Conflict of interest The Authors declare no conflict of interest

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References

    1. http://www.salute.gov.it/portale/nuovocoronavirus/dettaglioContenutiNuov....
    1. Baj J, Karakuła-Juchnowicz H, Teresiński G, et al. COVID-19: specific and non-specific clinical manifestations and symptoms: the current state of knowledge. J Clin Med 2020;9:1753 https://doi.org/10.3390/jcm9061753 10.3390/jcm9061753 - DOI - PMC - PubMed
    1. Bourgonje AR, Abdulle AE, Timens W, et al. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J Pathol 2020;251:228-48. https://doi.org/10.1002/path.5471 10.1002/path.5471 - DOI - PMC - PubMed
    1. Fotuhi M, Mian A, Meysami S, et al. Neurobiology of COVID-19. J Alzheimers Dis 2020;76:3-19. https://doi.org/10.3233/JAD-200581 10.3233/JAD-200581 - DOI - PMC - PubMed
    1. Tay MZ, Poh CM, Rénia L, et al. The trinity of COVID-19: immunity, inflammation, and intervention. Nat Rev Immunol 2020;20:363-74. https://doi.org/10.1038/s41577-020-0311-8 10.1038/s41577-020-0311-8 - DOI - PMC - PubMed