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Case Reports
. 2019 Oct 11;35(3):440-442.
doi: 10.46497/ArchRheumatol.2020.7541. eCollection 2020 Sep.

Tofacitinib Induced Psoriasiform Lesion in a Patient With Rheumatoid Arthritis

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Case Reports

Tofacitinib Induced Psoriasiform Lesion in a Patient With Rheumatoid Arthritis

Kemal Erol et al. Arch Rheumatol. .

Abstract

Paradoxical psoriasis or psoriasiform lesion is an adverse effect, represented by the occurrence of a psoriasiform lesion or exacerbation of psoriasis caused by the drugs normally used for the management of psoriasis. In this article, we present the first case of a 45-year-old male patient with rheumatoid arthritis who developed psoriasiform lesions following treatment with tofacitinib, and highlight the possible pathogenetic mechanisms involved in such an occurrence.

Keywords: Paradoxical; psoriasis; rheumatoid arthritis; tofacitinib.

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Conflict of interest statement

Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Figure 1
Figure 1. Lesions on patient’s arms.
Figure 2
Figure 2. Patient’s hand X-ray.
Figure 3
Figure 3. Pelvis anteroposterior X-ray.

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References

    1. Azevedo A, Torres T. Tofacitinib: A New Oral Therapy for Psoriasis. Clin Drug Investig. 2018;38:101–112. - PubMed
    1. Smolen JS, Landewé R, Bijlsma J, Burmester G, Chatzidionysiou K, Dougados M, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease- modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76:960–977. - PubMed
    1. Fiorino G, Danese S, Pariente B, Allez M. Paradoxical immune-mediated inflammation in inflammatory bowel disease patients receiving anti-TNF-a agents. Autoimmun Rev. 2014;13:15–19. - PubMed
    1. Kawalec P, Sladowska K, Malinowska-Lipien I, Brzostek T, Kózka M. European perspective on the management of rheumatoid arthritis: clinical utility of tofacitinib. Ther Clin Risk Manag. 2017;14:15–29. - PMC - PubMed
    1. Cinats A, Heck E, Robertson L. Janus kinase inhibitors: a review of their emerging applications in dermatology. Skin Therapy Lett. 2018;23:5–9. - PubMed

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