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Case Reports
. 2021 May 28;10(5):686-690.
doi: 10.1093/jpids/piab007.

Sixteen Weeks Later: Expanding the Risk Period for Multisystem Inflammatory Syndrome in Children

Blake T Cirks  1   2   3 , Samantha J Rowe  1 , Sarah Y Jiang  1 , Robert M Brooks  1 , Michael P Mulreany  1   2   4 , Wendy Hoffner  1   2 , Olcay Y Jones  1   2   5 , Patrick W Hickey  2
Affiliations
Case Reports

Sixteen Weeks Later: Expanding the Risk Period for Multisystem Inflammatory Syndrome in Children

Blake T Cirks et al. J Pediatric Infect Dis Soc. .

Abstract

Multisystem inflammatory syndrome in children (MIS-C) has been observed in temporal association with coronavirus disease 2019 (COVID-19), typically within 2 to 6 weeks of illness or exposure. We present a case of MIS-C occurring 16 weeks after initial COVID-19 illness to highlight the prolonged period of risk for developing MIS-C.

Keywords: multisystem inflammatory syndrome in children; myocarditis; novel coronavirus 2019; severe acute respiratory syndrome coronavirus 2.

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Figures

Figure 1.
Figure 1.
The graphical trend of pertinent lab values and temperature throughout hospitalization and the timing and dosing of anti-inflammatory treatment during the admission for multisystem inflammatory syndrome in children. Abbreviations: IVIG, intravenous immunoglobulin; Pro-BNP, pro-B-type natriuretic peptide; CRP, C-reactive protein; WBC, white blood cell; HD, hospital day; ED, Emergency Department.
See this image and copyright information in PMC

Comment in

  • MIS-C, Can Latency Interval Help in Diagnosis?
    Mosquera Fernández P, García García S, Epalza C, Blázquez-Gamero D, Carrasco J, Fernandez-Cook E, Prieto-Tato L, Torres D, Villaverde S, Belda S, Toral-Vázquez B, Moraleda C. Mosquera Fernández P, et al. Pediatr Infect Dis J. 2021 Jul 1;40(7):e281-e282. doi: 10.1097/INF.0000000000003150. Pediatr Infect Dis J. 2021. PMID: 34097666 No abstract available.
  • COVID-19 Vaccination Outcomes at a Pediatric Long-Term Care Facility.
    Bickel S, Harris C, Huxol H, Morton R. Bickel S, et al. Pediatr Infect Dis J. 2021 Jul 1;40(7):e281-e283. doi: 10.1097/INF.0000000000003185. Pediatr Infect Dis J. 2021. PMID: 34097667 No abstract available.

References

    1. Riphagen S, Gomez X, Gonzalez-Martinez C, et al. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020; 395:1607–8. - PMC - PubMed
    1. Centers for Disease Control and Prevention. Emergency preparedness and response: multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19). Accessed December 29, 2020. https://emergency.cdc.gov/han/2020/han00432.asp
    1. Centers for Disease Control and Prevention. Multisystem inflammatory syndrome (MIS-C). Accessed December 29, 2020. https://www.cdc.gov/mis-c/index.html
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Publication types

Supplementary concepts