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. 2021 Mar;48(3):344-352.
doi: 10.1111/1346-8138.15703. Epub 2021 Jan 17.

Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

Chao-Chun Yang  1   2 , Chin-Han Wu  3 , Tak-Wah Wong  1   4 , Feng-Jie Lai  5 , Kai-Che Wei  6 , Tzu-Kai Lin  7 , Chrang-Shi Lin  8 , Juemin Zhao  9 , Leihong Xiang  9 , Chao-Hsing Kao  10 , Ying-Jan Wang  11 , Cheng-Che Eric Lan  12 , Hamm-Ming Sheu  10
Affiliations

Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

Chao-Chun Yang et al. J Dermatol. 2021 Mar.

Abstract

SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.

Keywords: Solanum undatum; actinic keratosis; photoaging; photocarcinogenesis; solamargine.

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