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. 2021 May;51(5):1278-1281.
doi: 10.1002/eji.202048756. Epub 2021 Feb 9.

Generation of HBsAg-reactive T- and B-cells following HBV vaccination in serological non-responders under hemodialysis treatment

Toralf Roch  1   2 , Claudia Giesecke-Thiel  3   4 , Arturo Blazquez-Navarro  1   2 , Patrizia Wehler  1   2 , Constantin J Thieme  2 , Kerstin Juelke  5 , Gerald Grütz  5 , Jan Hörstrup  6 , Oliver Witzke  7 , Ulf Dittmer  8 , Ulrik Stervbo  2 , Petra Reinke  1   9 , Timm H Westhoff  2 , Nina Babel  1   2
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Free article

Generation of HBsAg-reactive T- and B-cells following HBV vaccination in serological non-responders under hemodialysis treatment

Toralf Roch et al. Eur J Immunol. 2021 May.
Free article

Abstract

HBV vaccination is recommend for hemodialysis patients, but only 50-60% of the patients show seroconversion. HBV vaccine-induced generation of HBV reactive T and B cells could be detected regardless of their capacity to mount a serological response, indicating that patients without seroconversion are potentially protected by their HBV-reactive T cell pool.

Keywords: T cells; anti-HBsAg titer; antigen-specific B cells; hepatitis B virus; renal diseases.

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