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. 2020 Dec 30;13(1):1473-1487.
doi: 10.18632/aging.202455. Epub 2020 Dec 30.

Prognostic relevance of SMC family gene expression in human sarcoma

Jian Zhou  1 , Gen Wu  1   2 , Zhongyi Tong  3 , Jingjing Sun  4 , Jing Su  5 , Ziqin Cao  1 , Yingquan Luo  6 , Wanchun Wang  1
Affiliations

Prognostic relevance of SMC family gene expression in human sarcoma

Jian Zhou et al. Aging (Albany NY). .

Abstract

Objective: To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma.

Results: We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to the Cancer Cell Line Encyclopedia (CCLE), SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 are also highly expressed in sarcoma cell lines. Results of Gene Expression Profiling Interactive Analysis (GEPIA) indicated that high expression of SMC1A was significantly related to poor overall survival (OS) (p<0.05) and disease-free survival (DFS) in sarcoma (p<0.05). Additionally, strong expression of SMC2 was significantly related to poor OS in sarcoma (p<0.05). In contrast, SMC3, SMC4, SMC5, and SMC6 expression had no significant impact on OS or DFS in sarcoma.

Conclusions: Expression of SMC family members is significantly different in sarcoma relative to normal tissues, and SMC1A and SMC2 may be useful as prognostic biomarkers.

Methods: We performed a detailed comparison of cancer and normal tissues regarding the expression levels of mRNA for SMC family members in various cancers including sarcoma through ONCOMINE and GEPIA (Gene Expression Profile Interactive Analysis) databases.

Keywords: SMC; bioinformatics analysis; expression; prognosis; sarcoma.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The Transcription Levels of SMC Factors in Different Types of Cancers (ONCOMINE).
Figure 2
Figure 2
The Expression of SMCs in Sarcoma (GEPIA). (A)The expression of SMC1A in pan-cancer. (B) The expression of SMC2 in pan-cancer. (C) The expression of SMC3 in pan-cancer.(D) The expression of SMC4 in pan-cancer.(E) The expression of SMC5 in pan-cancer.(F) The expression of SMC6 in pan-cancer. (G, H) The expression of SMCs in SARC.
Figure 3
Figure 3
The Expression of SMCs Sarcoma Cell Lines (CCLE). (A) The expression of SMC1A in sarcoma cell lines, analyzing by CCLE. (B) The expression of SMC2 in sarcoma cell lines, analyzed by CCLE. (C) The expression of SMC3 in sarcoma cell lines, analyzed by CCLE. (D) The expression of SMC4 in sarcoma cell lines, analyzed by CCLE. (E) The expression of SMC5 in sarcoma cell lines, analyzed by CCLE. (F) The expression of SMC6 in sarcoma cell lines, analyzed by CCLE.
Figure 4
Figure 4
The Expression of SMCs in synovial sarcoma (Immunohistochemistry). N: normal control; T: synovial sarcoma.
Figure 5
Figure 5
The Prognostic Value of mRNA Level of SMC Factors in Sarcoma Patients (GEPIA). (A) The prognostic value of mRNA level of SMC factors in disease-free survival (DFS) of sarcoma patients, (B) The prognostic value of mRNA level of SMC factors in over survival (OS) of sarcoma patients.
Figure 6
Figure 6
Co-expressed Genes of SMCs, and the Correction between SMCs in Sarcoma (ONCOMINE and GEPIA). (A) Co-expressed genes of SMCs in sarcoma, analyzed by ONCOMINE. (B) The correction between SMCs in sarcoma, analyzed by GEPIA.
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