Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun;77(6):2620-2625.
doi: 10.1002/ps.6285. Epub 2021 Feb 2.

Where are the new herbicides?

Ren-Yu Qu  1 , Bo He  1 , Jing-Fang Yang  1 , Hong-Yan Lin  1 , Wen-Chao Yang  1 , Qiong-You Wu  1 , Qing X Li  2 , Guang-Fu Yang  1
Affiliations
Review

Where are the new herbicides?

Ren-Yu Qu et al. Pest Manag Sci. 2021 Jun.

Abstract

Herbicide resistance has become one of the foremost problems in crop production worldwide. New herbicides are required to manage weeds that have evolved resistance to the existing herbicides. However, relatively few herbicides with new modes of action (MOAs) have been discovered in the past two decades. Therefore, the discovery of new herbicides (i.e., new chemical classes or MOAs) remains a primary but ongoing strategy to overcome herbicide resistance and ensure crop production. In this mini-review, starting with the inherent characteristics of the target proteins and the inhibitor structures, we propose two strategies for the rational design of new herbicides and one computational method for the risk evaluation of target mutation-conferred herbicide resistance. The information presented here may improve the utilization of known targets and inspire the discovery of herbicides with new targets. We believe that these strategies may trigger the sustainable development of herbicides in the future. © 2021 Society of Chemical Industry.

Keywords: glyphosate; herbicide; mode of action; resistance; target mutation.

PubMed Disclaimer

References

REFERENCES

    1. The Business Research Company, Pesticides Global Market Opportunities And Strategies, Sep. 2020, Pesticides Market - By Type (Herbicides, Fungicides And Insecticides), By Region, Opportunities And Strategies - Global Forecast To 2023. [Online]. Available: https://www.thebusinessresearchcompany.com/report/pesticides-market [7 December 2020].
    1. Gianessi LP, The increasing importance of herbicides in worldwide crop production. Pest Manage Sci 47:1099-1105 (2013).
    1. Lamberth C, Jeanmart S, Luksch T and Plant A, Current challenges and trends in the discovery of agrochemicals. Science 341:742-746 (2013).
    1. Mallory-Smith CA and Sanchez Olguin E, Gene flow from herbicide-resistant crops: It's not just for transgenes. J Agric Food Chem 59:5813-5818 (2011).
    1. Peterson MA, Collavo A, Ovejero R, Shivrain V and Walsh MJ, The challenge of herbicide resistance around the world: a current summary. Pest Manage Sci 74:2246-2259 (2018).

LinkOut - more resources