Assessing the importance of interleukin-6 in COVID-19 - Authors' reply

Affiliations

¹ Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Feinstein Institute for Medical Research, Manhasset, NY, USA. Electronic address: dleisman@mgh.harvard.edu.
² Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
³ Levy Library, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁴ Feinstein Institute for Medical Research, Manhasset, NY, USA; Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, NY, USA; Zucker School of Medicine at Hofstra-Northwell, New York, NY, USA.
⁵ Department of Anesthesiology, Division of Critical Care, Washington University School of Medicine in St Louis, St Louis, MO, USA.
⁶ Department of Anesthesia and Perioperative Care, University of California, San Francisco School of Medicine, San Francisco, CA, USA; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA; Cardiovascular Research Institute, University of California, San Francisco School of Medicine, San Francisco, CA, USA.
⁷ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁸ Division of Pulmonary and Critical Care Medicine, Northwell Health, New York, NY, USA.
⁹ Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Pulmonary and Critical Care Medicine, Northwell Health, New York, NY, USA.
¹⁰ Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Palliative and Advanced Illness Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹¹ Department of Anesthesia and Perioperative Care, University of California, San Francisco School of Medicine, San Francisco, CA, USA.

PMID: 33460572
PMCID: PMC7834405
DOI: 10.1016/S2213-2600(20)30603-2

Comment

Assessing the importance of interleukin-6 in COVID-19 - Authors' reply

Daniel E Leisman et al. Lancet Respir Med. 2021 Feb.

. 2021 Feb;9(2):e14-e15.

doi: 10.1016/S2213-2600(20)30603-2. Epub 2021 Jan 15.

Authors

Affiliations

¹ Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Feinstein Institute for Medical Research, Manhasset, NY, USA. Electronic address: dleisman@mgh.harvard.edu.
² Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
³ Levy Library, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁴ Feinstein Institute for Medical Research, Manhasset, NY, USA; Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, NY, USA; Zucker School of Medicine at Hofstra-Northwell, New York, NY, USA.
⁵ Department of Anesthesiology, Division of Critical Care, Washington University School of Medicine in St Louis, St Louis, MO, USA.
⁶ Department of Anesthesia and Perioperative Care, University of California, San Francisco School of Medicine, San Francisco, CA, USA; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA; Cardiovascular Research Institute, University of California, San Francisco School of Medicine, San Francisco, CA, USA.
⁷ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁸ Division of Pulmonary and Critical Care Medicine, Northwell Health, New York, NY, USA.
⁹ Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Pulmonary and Critical Care Medicine, Northwell Health, New York, NY, USA.
¹⁰ Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Palliative and Advanced Illness Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹¹ Department of Anesthesia and Perioperative Care, University of California, San Francisco School of Medicine, San Francisco, CA, USA.

PMID: 33460572
PMCID: PMC7834405
DOI: 10.1016/S2213-2600(20)30603-2

No abstract available

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Figures

**Figure**
Interleukin-6 concentrations in patients with COVID-19 versus comparison disorders Markers indicate the weighted pooled mean concentration for each disease group. Errors bars indicate 95% CIs. p values and 95% CI were computed for the difference in means between the indicated group versus COVID-19. ARDS=acute respiratory distress syndrome. CAR=chimeric antigen receptor. CRS=chimeric antigen receptor T cell-induced cytokine release syndrome.

See this image and copyright information in PMC

Comment on

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.
Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroiani F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS. Leisman DE, et al. Lancet Respir Med. 2020 Dec;8(12):1233-1244. doi: 10.1016/S2213-2600(20)30404-5. Epub 2020 Oct 16. Lancet Respir Med. 2020. PMID: 33075298 Free PMC article.
Assessing the importance of interleukin-6 in COVID-19.
Chen LYC, Hoiland RL, Stukas S, Wellington CL, Sekhon MS. Chen LYC, et al. Lancet Respir Med. 2021 Feb;9(2):e13. doi: 10.1016/S2213-2600(20)30600-7. Epub 2021 Jan 15. Lancet Respir Med. 2021. PMID: 33460569 Free PMC article. No abstract available.

References

1. Leisman DE, Ronner L, Pinotti R, et al. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med. 2020;8:1233–1244. - PMC - PubMed
1. Cummings MJ, Baldwin MR, Abrams D, et al. Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study. Lancet. 2020;395:1763–1770. - PMC - PubMed
1. Stone JH, Frigault MJ, Serling-Boyd NJ, et al. Efficacy of tocilizumab in patients hospitalized with Covid-19. N Engl J Med. 2020;383:2333–2344. - PMC - PubMed
1. Hermine O, Mariette X, Tharaux PL, et al. Effect of tocilizumab vs usual care in adults hospitalized with COVID-19 and moderate or severe pneumonia: a randomized clinical trial. JAMA Intern Med. 2021;181:32–40. - PMC - PubMed
1. Salvarani C, Dolci G, Massari M, et al. Effect of tocilizumab vs standard care on clinical worsening in patients hospitalized with COVID-19 pneumonia: a randomized clinical trial. JAMA Intern Med. 2021;181:24–31. - PMC - PubMed

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Assessing the importance of interleukin-6 in COVID-19 - Authors' reply

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