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Case Reports
. 2021 Jan 18;14(1):e240178.
doi: 10.1136/bcr-2020-240178.

Late onset of Guillain-Barré syndrome following SARS-CoV-2 infection: part of 'long COVID-19 syndrome'?

Mina M Raahimi  1 , Alice Kane  2 , Christopher Eg Moore  3 , Ahmad W Alareed  3
Affiliations
Case Reports

Late onset of Guillain-Barré syndrome following SARS-CoV-2 infection: part of 'long COVID-19 syndrome'?

Mina M Raahimi et al. BMJ Case Rep. .

Abstract

We describe a case of delayed onset, acute demyelinating neuropathy secondary to novel SARS-CoV-2 infection. A previously healthy 46-year-old man presented with bilateral leg pain and loss of sensation in his feet 53 days after having COVID-19 pneumonitis. He developed painful sensory symptoms followed by a rapidly progressive lower motor neuron weakness involving all limbs, face and respiratory muscles, needing ventilatory support. In keeping with a diagnosis of Guillain-Barré syndrome, cerebrospinal fluid examination showed albuminocytologic dissociation and nerve conduction studies supported the diagnosis of an acute inflammatory demyelinating polyradiculoneuropathy. The delayed neurological dysfunction seen in our patient following SARS-CoV-2 infection may indicate a novel mechanism of disease that is part of the emerging 'long COVID-19 syndrome'.

Keywords: COVID-19; immunology; infectious diseases; neurology.

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Conflict of interest statement

Competing interests: None declared.

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References

    1. Pezzini A, Padovani A. Lifting the mask on neurological manifestations of COVID-19. Nat Rev Neurol 2020;16:636–44. 10.1038/s41582-020-0398-3 - DOI - PMC - PubMed
    1. Othenin-Girard A, Regamey J, Lamoth F, et al. . Multisystem inflammatory syndrome with refractory cardiogenic shock due to acute myocarditis and mononeuritis multiplex after SARS-CoV-2 infection in an adult. Swiss Med Wkly 2020;150:w20387. 10.4414/smw.2020.20387 - DOI - PubMed
    1. Needham E, Newcombe V, Michell A. Mononeuritis multiplex: an unexpectedly common feature of severe COVID-19. medRxiv 2020. 10.1101/2020.07.19.20149898 - DOI - PMC - PubMed
    1. Garrigues E, Janvier P, Kherabi Y, et al. . Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. J Infect 2020;81:e4–6. 10.1016/j.jinf.2020.08.029 - DOI - PMC - PubMed
    1. Carfì A, Bernabei R, Landi F, et al. . Persistent symptoms in patients after acute COVID-19. JAMA 2020;324:603–5. 10.1001/jama.2020.12603 - DOI - PMC - PubMed

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