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. 2021 Aug 16;73(4):726-729.
doi: 10.1093/cid/ciab045.

Waning Vaccine Effectiveness Against Influenza-Associated Hospitalizations Among Adults, 2015-2016 to 2018-2019, United States Hospitalized Adult Influenza Vaccine Effectiveness Network

Jill M Ferdinands  1 , Manjusha Gaglani  2 , Emily T Martin  3 , Arnold S Monto  3 , Donald Middleton  4 , Fernanda Silveira  4 , H Keipp Talbot  5 , Richard Zimmerman  4 , Manish Patel  1
Affiliations

Waning Vaccine Effectiveness Against Influenza-Associated Hospitalizations Among Adults, 2015-2016 to 2018-2019, United States Hospitalized Adult Influenza Vaccine Effectiveness Network

Jill M Ferdinands et al. Clin Infect Dis. .

Abstract

We observed decreased effectiveness of influenza vaccine with increasing time since vaccination for prevention of influenza A(H3N2), influenza A(H1N1)pdm09, and influenza B/Yamagata-associated hospitalizations among adults. Maximum vaccine effectiveness (VE) was observed shortly after vaccination, followed by an absolute decline in VE of about 8%-9% per month postvaccination.

Keywords: adults; hospitalization; influenza; vaccine effectiveness; waning.

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