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. 2021 Jul;14(4):435-445.
doi: 10.1007/s40271-020-00476-x. Epub 2021 Jan 19.

Developing a Framework for Public Involvement in Mathematical and Economic Modelling: Bringing New Dynamism to Vaccination Policy Recommendations

Sophie Staniszewska  1 , Edward M Hill  2 , Richard Grant  3 , Peter Grove  4 , Jarina Porter  3 , Tinevimbo Shiri  5 , Sue Tulip  3 , Jane Whitehurst  3 , Claire Wright  6 , Samik Datta  7 , Stavros Petrou  8   9 , Matt Keeling  2
Affiliations

Developing a Framework for Public Involvement in Mathematical and Economic Modelling: Bringing New Dynamism to Vaccination Policy Recommendations

Sophie Staniszewska et al. Patient. 2021 Jul.

Erratum in

Abstract

Objectives: The Mathematical and Economic Modelling for Vaccination and Immunisation Evaluation (MEMVIE) programme aimed to explore, capture and support the potential contribution of the public to mathematical and economic modelling, in order to identify the values that underpin public involvement (PI) in modelling and co-produce a framework that identifies the nature and type of PI in modelling and supports its implementation.

Methods: We established a PI Reference Group, who worked collaboratively with the academic contributors to create a deliberative knowledge space, which valued different forms of knowledge, expertise and evidence. Together, we explored the key steps of mathematical and economic methods in 21 meetings during 2015-2020. These deliberations generated rich discussion, through which we identified potential points of public contribution and the values that underpin PI in modelling. We iteratively developed a framework to guide future practice of PI in modelling.

Results: We present the MEMVIE Public Involvement Framework in two forms: a short form to summarise key elements, and a long form framework to provide a detailed description of each potential type of public contribution at each stage of the modelling process. At a macro level, the public can contribute to reviewing context, reviewing relevance, assessing data and justifying model choice, troubleshooting, and interpreting and reviewing outcomes and decision making. The underpinning values that drive involvement include the public contributing to the validity of the model, potentially enhancing its relevance, utility and transparency through diverse inputs, and enhancing the credibility, consistency and continuous development through scrutiny, in addition to contextualising the model within a wider societal view.

Discussion and conclusion: PI in modelling is in its infancy. The MEMVIE Framework is the first attempt to identify potential points of collaborative public contribution to modelling, but it requires further evaluation and refinement that we are undertaking in a subsequent study.

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Conflict of interest statement

CW is employed by the Meningitis Research Foundation, which has received grants and conference sponsorship from Pfizer, GlaxoSmithKline, and Sanofi Pasteur. Sophie Staniszewska, Edward M. Hill, Richard Grant, Peter Grove, Jarina Porter, Tinevimbo Shiri, Sue Tulip, Jane Whitehurst, Samik Datta, Stavros Petrou, and Matt Keeling these authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
The left-hand side of the framework represents the epidemiological components of modelling, while the middle section represents the health economic components of the modelling. Each phase is labelled Ep (epidemiological) or Ec (economic), corresponding to the associated section of the long-form framework (Appendix 2). The framework should be read across horizontally, i.e. Ep1, then Ec1, Ep2, Ec2, and so on. The legend on the right-hand side denotes the five types of PI contribution identified by the reference group. Patterned backgrounds illustrate the regions of the model pathway where the associated PI contribution type predominately features. PI public involvement, QALYs quality-adjusted life-years, GP General Practitioner
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References

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