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Review
. 2022 Mar;41(2):314-337.
doi: 10.1002/mas.21681. Epub 2021 Jan 18.

Fourier transform ion cyclotron resonance mass spectrometry at the true cyclotron frequency

Konstantin O Nagornov  1 , Oleg Y Tsybin  2 , Edith Nicol  3 , Anton N Kozhinov  1 , Yury O Tsybin  1
Affiliations
Review

Fourier transform ion cyclotron resonance mass spectrometry at the true cyclotron frequency

Konstantin O Nagornov et al. Mass Spectrom Rev. 2022 Mar.

Abstract

Ion cyclotron resonance (ICR) cells provide stability and coherence of ion oscillations in crossed electric and magnetic fields over extended periods of time. Using the Fourier transform enables precise measurements of ion oscillation frequencies. These precisely measured frequencies are converted into highly accurate mass-to-charge ratios of the analyte ions by calibration procedures. In terms of resolution and mass accuracy, Fourier transform ICR mass spectrometry (FT-ICR MS) offers the highest performance of any MS technology. This is reflected in its wide range of applications. However, in the most challenging MS application, for example, imaging, enhancements in the mass accuracy of fluctuating ion fluxes are required to continue advancing the field. One approach is to shift the ion signal power into the peak corresponding to the true cyclotron frequency instead of the reduced cyclotron frequency peak. The benefits of measuring the true cyclotron frequency include increased tolerance to electric fields within the ICR cell, which enhances frequency measurement precision. As a result, many attempts to implement this mode of FT-ICR MS operation have occurred. Examples of true cyclotron frequency measurements include detection of magnetron inter-harmonics of the reduced cyclotron frequency (i.e., the sidebands), trapping field-free (i.e., screened) ICR cells, and hyperbolic ICR cells with quadrupolar ion detection. More recently, ICR cells with spatially distributed ion clouds have demonstrated attractive performance characteristics for true cyclotron frequency ion detection. Here, we review the corresponding developments in FT-ICR MS over the past 40 years.

Keywords: FTMS; Fourier transform mass spectrometry; ICR; NADEL; cyclotron frequency; cyclotron oscillators; ion cyclotron resonance; narrow aperture detection electrodes; quadrupolar ion detection; reduced cyclotron frequency; space charge; true cyclotron frequency.

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References

REFERENCES

    1. Allemann M, Kellerhals HP, Wanczek KP. 1981. Sidebands in the ICR spectrum and their application for exact mass determination. Chem Phys Lett 84:547-551.
    1. Amster IJ. 1996. Fourier transform mass spectrometry. J Mass Spectrom 31:1325-1337.
    1. Aushev T, Kozhinov AN, Tsybin YO. 2014. Least-squares fitting of time-domain signals for Fourier transform mass spectrometry. J Am Soc Mass Spectrom 25:1263-1273.
    1. Boldin IA, Nikolaev EN. 2011. Fourier transform ion cyclotron resonance cell with dynamic harmonization of the electric field in the whole volume by shaping of the excitation and detection electrode assembly. Rapid Commun Mass Spectrom 25:122-126.
    1. Bowman AP, Blakney GT, Hendrickson CL, Ellis SR, Heeren RMA, Smith DF. 2020. Ultra-high mass resolving power, mass accuracy, and dynamic range MALDI mass spectrometry imaging by 21-T FT-ICR MS. Anal Chem 92:3133-3142.

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