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Review
. 2021 Jan 19;23(3):8.
doi: 10.1007/s11883-021-00905-8.

Diabetes, Lipids, and CV Risk

Jan Škrha Jr  1
Affiliations
Review

Diabetes, Lipids, and CV Risk

Jan Škrha Jr. Curr Atheroscler Rep. .

Abstract

Purpose of review: Diabetes is often associated with diabetic dyslipidemia. Both hyperglycemia and disorders of lipid metabolism strongly contribute to development of atherosclerosis, the crucial factor of cardiovascular disease. The aim of the manuscript is to summarize possible treatment to reduce cardiovascular risk.

Recent findings: Maximal cardiovascular risk reduction is maintained by targeting more pathologic disturbances together. While antihypertensive treatment has not changed much recently, novel PCSK9 inhibitors have significantly improved management of dyslipidemia. Similarly, modern antihyperglycemic agents (SGLT2 inhibitors and GLP-1 receptor agonists) show both significant metabolic effects and cardiovascular benefits. Diabetes treatment is no longer glucocentric. Apart from glucose management, there are effective pharmacologic tools for significant reduction of cardiovascular risk.

Keywords: Atherosclerosis; Cardiovascular risk; Diabetes; Prevention.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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