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Meta-Analysis
. 2021 Aug;131(8):1845-1854.
doi: 10.1002/lary.29393. Epub 2021 Jan 19.

Cochlear Implantation in Meniere's Disease: A Systematic Review and Meta-Analysis

Dillan F Villavisanis  1 , Maria A Mavrommatis  1 , Elisa R Berson  2 , Christopher P Bellaire  1 , John W Rutland  3 , Caleb J Fan  1 , George B Wanna  1 , Maura K Cosetti  1
Affiliations
Meta-Analysis

Cochlear Implantation in Meniere's Disease: A Systematic Review and Meta-Analysis

Dillan F Villavisanis et al. Laryngoscope. 2021 Aug.

Abstract

Objectives/hypothesis: Meniere's disease (MD) is a debilitating condition characterized by hearing loss, vertigo, and tinnitus. The objective of this study was to systematically investigate outcomes in MD after cochlear implantation (CoI), with and without labyrinthectomy.

Study design: Systematic review and meta-analysis.

Methods: A systematic review of articles in Medline and Embase was performed to identify all studies of patients with MD who underwent CoI. This analysis evaluates outcomes of speech recognition, pure tone audiometry, vertigo, tinnitus, and quality of life.

Results: Of 321 studies identified, 37 were included, involving 216 patients. Mean age at implantation was 61.4 years (range 27-85 years) with average length of follow-up at 1.7 years (range 0-9 years). Forty-four (20.4%) patients underwent labyrinthectomy. Meta-analysis demonstrated significant improvements in audiometric outcomes following CoI. There was a statistically significant improvement in Hearing in Noise Test performance, with a mean difference improvement of 44.7 (95% confidence interval [CI] [8.8, 80.6]) at 6 months and 60.1 (95% CI [35.3, 85.0]) at 12 months. The Freiburger Monosyllabic Test (FMT) and Consonant-Nucleus-Consonant (CNC) also improved significantly, with mean difference improvements of 46.2 (95% CI [30.0, 62.4]) for FMT and 19.3 (95% CI [8.1, 30.4]) for CNC. There was a statistically significant decrease in tinnitus, as measured by a mean difference reduction of 48.1 (95% CI [1.0, 95.2]) in the Tinnitus Handicap Index.

Conclusions: CoI with and without simultaneous labyrinthectomy is a viable treatment option for patients with MD, yielding high rates of tinnitus suppression and vertigo control. Post-CoI MD patients demonstrate similar postoperative speech perception outcomes to non-MD implant recipients. Laryngoscope, 131:1845-1854, 2021.

Keywords: Meniere's disease; cochlear implant; deafness; dizziness; endolymphatic hydrops; hearing loss; speech recognition; tinnitus; vertigo.

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References

BIBLIOGRAPHY

    1. Minor LB, Schessel DA, Carey JP. Meniere's disease. Curr Opin Neurol 2004;17:9-16.
    1. Huppert D, Strupp M, Bradt T. Long-term course of Meniere's disease revisited. Acta Otolaryngol 2010;130:644-651.
    1. Basura GJ, Adams ME, Monfared A, et al. Clinical practice guideline: Meniere's disease. J Otolaryngol Head Neck Surg 2020;162:S1-S55.
    1. Wareing M, O'Connor AF. The role of labyrinthectomy and cochlear implantation. Ear Nose Throat J 1997;76:664-669.
    1. Hansen M, Gantz B, Dunn C. Outcomes after cochlear implantation for patients with single-sided deafness, including those with recalcitrant Meniere's disease. Otol Neurotol 2013;34:1681-1687.

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