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Review
. 2021 Jan 5;13(1):154.
doi: 10.3390/nu13010154.

Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review

Seung-Hyeok Park  1 , Minsun Kim  2 , Somi Lee  2 , Woojin Jung  2 , Bonglee Kim  2   3
Affiliations
Review

Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review

Seung-Hyeok Park et al. Nutrients. .

Abstract

Cervical cancer is the fourth most common cancer among women worldwide. Though several natural products have been reported regarding their efficacies against cervical cancer, there has been no review article that categorized them according to their anti-cancer mechanisms. In this study, anti-cancerous natural products against cervical cancer were collected using Pubmed (including Medline) and google scholar, published within three years. Their mechanisms were categorized as induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis, reduction of resistance, and regulation of miRNAs. A total of 64 natural products suppressed cervical cancer. Among them, Penicillium sclerotiorum extracts from Cassia fistula L., ethanol extracts from Bauhinia variegate candida, thymoquinone obtained from Nigella sativa, lipid-soluble extracts of Pinellia pedatisecta Schott., and 1'S-1'-acetoxychavicol extracted from Alpinia conchigera have been shown to have multi-effects against cervical cancer. In conclusion, natural products could be attractive candidates for novel anti-cancer drugs.

Keywords: angiogenesis; apoptosis; cervical cancer; dietary natural products; metastasis; microRNA; resistance.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of compounds derived from natural products inducing apoptosis.
Figure 2
Figure 2
Chemical structures of compounds derived from natural products inhibiting metastasis.
Figure 3
Figure 3
Schematic diagram of drugs resistance signal pathways regulated by natural products in cervical cancer.
Figure 4
Figure 4
Chemical structures of compounds derived from natural products sensitizing drug resistance.
Figure 5
Figure 5
Schematic diagram of miRNAs regulated by natural products in cervical cancer.
See this image and copyright information in PMC

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