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. 2021 Jan 14;10(2):283.
doi: 10.3390/jcm10020283.

A Pragmatic Application of Ultrasonography for the Assessment of Disease Activity in Patients with Early Inflammatory Arthritis

Seoung Wan Nam  1 , Taeyoung Kang  2
Affiliations

A Pragmatic Application of Ultrasonography for the Assessment of Disease Activity in Patients with Early Inflammatory Arthritis

Seoung Wan Nam et al. J Clin Med. .

Abstract

The aim of the study was to examine the usefulness of targeted musculoskeletal ultrasonography (MSUS) in assessing the disease activity of patients with early inflammatory arthritis (EIA). Twenty-eight patients with EIA were enrolled. The MSUS examination of joints with arthritic signs (tenderness or swelling), measurement of 28-joint Disease Activity Score (DAS28), and its components were performed at four-week interval visits until power doppler (PD) US remission was achieved. Various MSUS parameters of grey scale (GS) and PD synovitis were measured. Pearson or Spearman correlation coefficients were determined for the purpose of the study. Data were gathered from a total of 85 visits. The Sum of GS grade correlated better with physical examination findings, while the Sum of PD grade correlated better with serum inflammatory markers and patient global health. However, Global OMERACT-EULAR Synovitis Score (GLOESS), which reflected both PD and GS grades, correlated evenly well with each clinical parameter. In addition, GLOESS correlated best with DAS28 in the overall study population (p < 0.01). Conclusively, our targeted MSUS parameters of arthritic joints, especially sums of semi-quantitative grades of synovitis, could be useful in monitoring patients with EIA.

Keywords: disease activity; early inflammatory arthritis; ultrasonography.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Patient selection flow. US, Ultrasonography; PDUS, Power doppler ultrasonography; GSUS, Grey scale ultrasonography.
See this image and copyright information in PMC

References

    1. Naredo E., Collado P., Cruz A., Palop M.J., Cabero F., Richi P., Carmona L., Crespo M. Longitudinal power doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: Predictive value in disease activity and radiologic progression. Arthritis Rheum. 2007;57:116–124. doi: 10.1002/art.22461. - DOI - PubMed
    1. Filer A., de Pablo P., Allen G., Nightingale P., Jordan A., Jobanputra P., Bowman S., Buckley C.D., Raza K. Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis. Ann. Rheum. Dis. 2011;70:500–507. doi: 10.1136/ard.2010.131573. - DOI - PMC - PubMed
    1. Salaffi F., Ciapetti A., Gasparini S., Carotti M., Filippucci E., Grassi W. A clinical prediction rule combining routine assessment and power doppler ultrasonography for predicting progression to rheumatoid arthritis from early-onset undifferentiated arthritis. Clin. Exp. Rheumatol. 2010;28:686–694. - PubMed
    1. Zufferey P., Rebell C., Benaim C., Ziswiler H.R., Dumusc A., So A. Ultrasound can be useful to predict an evolution towards rheumatoid arthritis in patients with inflammatory polyarthralgia without anticitrullinated antibodies. Joint Bone Spine. 2017;84:299–303. doi: 10.1016/j.jbspin.2016.05.011. - DOI - PubMed
    1. Funck-Brentano T., Gandjbakhch F., Etchepare F., Jousse-Joulin S., Miquel A., Cyteval C., Lukas C., Tobon G.J., Saraux A., Boumier P., et al. Prediction of radiographic damage in early arthritis by sonographic erosions and power doppler signal: A longitudinal observational study. Arthritis Care Res. (Hoboken) 2013;65:896–902. doi: 10.1002/acr.21912. - DOI - PubMed

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