Association of First-Week Nutrient Intake and Extrauterine Growth Restriction in Moderately Preterm Infants: A Regional Population-Based Study

doi:10.3390/nu13010227

Observational Study

. 2021 Jan 14;13(1):227.

doi: 10.3390/nu13010227.

Association of First-Week Nutrient Intake and Extrauterine Growth Restriction in Moderately Preterm Infants: A Regional Population-Based Study

Marine Baillat¹, Vanessa Pauly², Gina Dagau³, Julie Berbis², Farid Boubred^{1

4}, Laurence Fayol^{1

5}

Affiliations

¹ Department of Neonatology, Hôpital La Conception, Hôpitaux Universitaires de Marseille, 13005 Marseille, France.
² Research Unit EA 3279 and Department of Public Health, Aix-Marseille University, 13005 Marseille, France.
³ Service de Néonatologie, Centre Hospitalier de Martigues, 13698 Martigues CEDEX, France.
⁴ Aix-Marseille Université, C2VN, INRAE, INSERM, 13005 Marseille, France.
⁵ Réseau Périnatal Méditerranée (PACA-Corse-Monaco), 13015 Marseille, France.

PMID: 33466801
PMCID: PMC7830065
DOI: 10.3390/nu13010227

Observational Study

Association of First-Week Nutrient Intake and Extrauterine Growth Restriction in Moderately Preterm Infants: A Regional Population-Based Study

Marine Baillat et al. Nutrients. 2021.

. 2021 Jan 14;13(1):227.

doi: 10.3390/nu13010227.

Authors

Marine Baillat¹, Vanessa Pauly², Gina Dagau³, Julie Berbis², Farid Boubred^{1

4}, Laurence Fayol^{1

5}

Affiliations

¹ Department of Neonatology, Hôpital La Conception, Hôpitaux Universitaires de Marseille, 13005 Marseille, France.
² Research Unit EA 3279 and Department of Public Health, Aix-Marseille University, 13005 Marseille, France.
³ Service de Néonatologie, Centre Hospitalier de Martigues, 13698 Martigues CEDEX, France.
⁴ Aix-Marseille Université, C2VN, INRAE, INSERM, 13005 Marseille, France.
⁵ Réseau Périnatal Méditerranée (PACA-Corse-Monaco), 13015 Marseille, France.

PMID: 33466801
PMCID: PMC7830065
DOI: 10.3390/nu13010227

Abstract

The purpose of this study was to determine the influence of first-week nutrition intake on neonatal growth in moderate preterm (MP) infants. Data on neonatal morbidity and nutrition intake on day of life 7 (DoL7) were prospectively collected from 735 MP infants (32^0/7-34^6/7 weeks gestational age (GA)). Multivariable regression was used to assess the factors associated with extrauterine growth restriction (EUGR) defined as a decrease of more than 1 standard deviation (SD) in the weight z-score during hospitalization. Mean (SD) gestational age and birth weight were 33.2 (0.8) weeks and 2005 (369) g. The mean change in the weight z-score during hospitalization was -0.64 SD. A total of 138 infants (18.8%) had EUGR. Compared to adequate growth infants, EUGR infants received 15% and 35% lower total energy and protein intake respectively (p < 0.001) at DoL7. At DoL7, each increase of 10 kcal/kg/d and 1 g/kg/d of protein was associated with reduced odds of EUGR with an odds ratio of 0.73 (95% CI, 0.66-0.82; p < 0.001) and 0.54 (0.44-0.67; p < 0.001), respectively. Insufficient energy and protein intakes on DoL7 negatively affected neonatal growth of MP infants. Nutritional support should be optimized from birth onwards to improve neonatal weight growth.

Keywords: energy; extrauterine growth restriction; growth; moderately preterm; nutrition; premature infant; protein.

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Conflict of interest statement

The authors and collaborators declare no conflict of interest.

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References

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[1] Goldenberg R.L., Culhane J.F., Iams J.D., Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371:75–84. doi: 10.1016/S0140-6736(08)60074-4. - DOI - PMC - PubMed

[2] Goldenberg R.L., Culhane J.F., Iams J.D., Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371:75–84. doi: 10.1016/S0140-6736(08)60074-4. - DOI - PMC - PubMed

[3] Blencowe H., Cousens S., Chou D., Oestergaard M., Say L., Moller A.-B., Kinney M., Lawn J., Born Too Soon Preterm Birth Action Group Born too soon: The global epidemiology of 15 million preterm births. Reprod. Heal. 2013;10:S2. doi: 10.1186/1742-4755-10-S1-S2. - DOI - PMC - PubMed

[4] Blencowe H., Cousens S., Chou D., Oestergaard M., Say L., Moller A.-B., Kinney M., Lawn J., Born Too Soon Preterm Birth Action Group Born too soon: The global epidemiology of 15 million preterm births. Reprod. Heal. 2013;10:S2. doi: 10.1186/1742-4755-10-S1-S2. - DOI - PMC - PubMed

[5] Altman M., Vanpee M., Cnattingius S., Norman M. Neonatal morbidity in moderately preterm infants: A Swedish national population-based study. J. Pediatr. 2011;158:239–244.e1. doi: 10.1016/j.jpeds.2010.07.047. - DOI - PubMed

[6] Altman M., Vanpee M., Cnattingius S., Norman M. Neonatal morbidity in moderately preterm infants: A Swedish national population-based study. J. Pediatr. 2011;158:239–244.e1. doi: 10.1016/j.jpeds.2010.07.047. - DOI - PubMed

[7] Boyle E.M., Johnson S., Manktelow B., Seaton S.E., Draper E.S., Smith L.K., Dorling J., Marlow N., Petrou S., Field D.J. Neonatal outcomes and delivery of care for infants born late preterm or moderately preterm: A prospective population-based study. Arch. Dis. Child. Fetal Neonatal Ed. 2015;100:F479–F485. doi: 10.1136/archdischild-2014-307347. - DOI - PMC - PubMed

[8] Boyle E.M., Johnson S., Manktelow B., Seaton S.E., Draper E.S., Smith L.K., Dorling J., Marlow N., Petrou S., Field D.J. Neonatal outcomes and delivery of care for infants born late preterm or moderately preterm: A prospective population-based study. Arch. Dis. Child. Fetal Neonatal Ed. 2015;100:F479–F485. doi: 10.1136/archdischild-2014-307347. - DOI - PMC - PubMed

[9] Escobar G.J., Clark R.H., Greene J.D. Short-term outcomes of infants born at 35 and 36 weeks gestation: We need to ask more questions. Semin. Perinatol. 2006;30:28–33. doi: 10.1053/j.semperi.2006.01.005. - DOI - PubMed

[10] Escobar G.J., Clark R.H., Greene J.D. Short-term outcomes of infants born at 35 and 36 weeks gestation: We need to ask more questions. Semin. Perinatol. 2006;30:28–33. doi: 10.1053/j.semperi.2006.01.005. - DOI - PubMed

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Association of First-Week Nutrient Intake and Extrauterine Growth Restriction in Moderately Preterm Infants: A Regional Population-Based Study

Affiliations

Association of First-Week Nutrient Intake and Extrauterine Growth Restriction in Moderately Preterm Infants: A Regional Population-Based Study

Authors

Affiliations

Abstract

Conflict of interest statement

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References

Publication types

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LinkOut - more resources

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Medical