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Review
. 2021 Jan 16;14(1):70.
doi: 10.3390/ph14010070.

Endogenous Retroviruses in Nervous System Disorders

Victoria Gröger  1 , Alexander Emmer  2 , Martin S Staege  3 , Holger Cynis  1
Affiliations
Review

Endogenous Retroviruses in Nervous System Disorders

Victoria Gröger et al. Pharmaceuticals (Basel). .

Abstract

Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.

Keywords: amyotrophic lateral sclerosis; human endogenous retrovirus; monoclonal antibodies; multiple sclerosis.

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Conflict of interest statement

The authors declare no conflict of interest.

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