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Randomized Controlled Trial
. 2021 Jan 16;13(1):248.
doi: 10.3390/nu13010248.

Differential Effects of DHA- and EPA-Rich Oils on Sleep in Healthy Young Adults: A Randomized Controlled Trial

Michael J Patan  1 , David O Kennedy  1 , Cathrine Husberg  2 , Svein Olaf Hustvedt  2 , Philip C Calder  3   4 , Benita Middleton  5 , Julie Khan  1 , Joanne Forster  1 , Philippa A Jackson  1
Affiliations
Randomized Controlled Trial

Differential Effects of DHA- and EPA-Rich Oils on Sleep in Healthy Young Adults: A Randomized Controlled Trial

Michael J Patan et al. Nutrients. .

Abstract

Emerging evidence suggests that adequate intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs), which include docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), might be associated with better sleep quality. N-3 PUFAs, which must be acquired from dietary sources, are typically consumed at suboptimal levels in Western diets. Therefore, the current placebo-controlled, double-blind, randomized trial, investigated the effects of an oil rich in either DHA or EPA on sleep quality in healthy adults who habitually consumed low amounts of oily fish. Eighty-four participants aged 25-49 years completed the 26-week intervention trial. Compared to placebo, improvements in actigraphy sleep efficiency (p = 0.030) and latency (p = 0.026) were observed following the DHA-rich oil. However, these participants also reported feeling less energetic compared to the placebo (p = 0.041), and less rested (p = 0.017), and there was a trend towards feeling less ready to perform (p = 0.075) than those given EPA-rich oil. A trend towards improved sleep efficiency was identified in the EPA-rich group compared to placebo (p = 0.087), along with a significant decrease in both total time in bed (p = 0.032) and total sleep time (p = 0.019) compared to the DHA-rich oil. No significant effects of either treatment were identified for urinary excretion of the major melatonin metabolite 6-sulfatoxymelatonin. This study was the first to demonstrate some positive effects of dietary supplementation with n-3 PUFAs in healthy adult normal sleepers, and provides novel evidence showing the differential effects of n-3 PUFA supplements rich in either DHA or EPA. Further investigation into the mechanisms underpinning these observations including the effects of n-3 PUFAs on sleep architecture are required.

Keywords: SMEDS; actigraphy; docosahexaenoic acid; eicosapentaenoic acid; omega-3; sleep.

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Conflict of interest statement

C.H. and S.O.H. are employees of BASF AS. P.C.C. is an advisor to and has previously received funding from BASF AS.

Figures

Figure 1
Figure 1
Participant disposition through the trial. Figure depicts the disposition of participants throughout the study, culminating in n = 84 of the 90 who were randomized.
Figure 2
Figure 2
Estimated marginal means and standard error (SE) for post-treatment values of sleep efficiency (A), sleep latency (B), total minutes in bed (C), and total sleep time in minutes (D).
Figure 3
Figure 3
Estimated marginal means and standard error (SE) for post-treatment subjective ratings for feeling energetic, feeling rested, and feeling ready to perform, by treatment group.
See this image and copyright information in PMC

References

    1. Frank S., Gonzalez K., Lee-Ang L., Young M.C., Tamez M., Mattei J. Diet and Sleep Physiology: Public Health and Clinical Implications. Front. Neurol. 2017;8 doi: 10.3389/fneur.2017.00393. - DOI - PMC - PubMed
    1. St-Onge M.P., Mikic A., Pietrolungo C.E. Effects of Diet on Sleep Quality. Adv. Nutr. 2016;7:938–949. doi: 10.3945/an.116.012336. - DOI - PMC - PubMed
    1. Ji X., Grandner M.A., Liu J. The relationship between micronutrient status and sleep patterns: A systematic review. Public Health Nutr. 2017;20:687–701. doi: 10.1017/S1368980016002603. - DOI - PMC - PubMed
    1. Pusceddu M.M., Kelly P., Stanton C., Cryan J.F., Dinan T.G. N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology. Int. J. Neuropsychopharmacol. 2016;19:pyw078. doi: 10.1093/ijnp/pyw078. - DOI - PMC - PubMed
    1. Da Silva A.X., Lavialle F., Gendrot G., Guesnet P., Alessandri J.M., Lavialle M. Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids. J. Neurochem. 2002;81:1328–1337. doi: 10.1046/j.1471-4159.2002.00932.x. - DOI - PubMed

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