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Review
. 2021 Jan 16;26(2):458.
doi: 10.3390/molecules26020458.

A Review: Halogenated Compounds from Marine Fungi

Cong Wang  1   2 , Huanyun Lu  1 , Jianzhou Lan  1 , K H Ahammad Uz Zaman  2 , Shugeng Cao  2
Affiliations
Review

A Review: Halogenated Compounds from Marine Fungi

Cong Wang et al. Molecules. .

Abstract

Marine fungi produce many halogenated metabolites with a variety of structures, from acyclic entities with a simple linear chain to multifaceted polycyclic molecules. Over the past few decades, their pharmaceutical and medical application have been explored and still the door is kept open due to the need of new drugs from relatively underexplored sources. Biological properties of halogenated compounds such as anticancer, antiviral, antibacterial, anti-inflammatory, antifungal, antifouling, and insecticidal activity have been investigated. This review describes the chemical structures and biological activities of 217 halogenated compounds derived mainly from Penicillium and Aspergillus marine fungal strains reported from 1994 to 2019.

Keywords: chemical structures; halogenated compounds; marine fungi; natural products.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of compounds 1–38.
Figure 2
Figure 2
Structures of compounds 39–84.
Figure 3
Figure 3
Structures of compounds 85–113.
Figure 4
Figure 4
Structures of compounds 114–151.
Figure 5
Figure 5
Structures of compounds 152–217.
Figure 6
Figure 6
Numbers of new halogenated compounds reported annually from 1994–2019.
Figure 7
Figure 7
Journals that reported new halogenated compounds and numbers of papers published (1994–2019).
Figure 8
Figure 8
Percentages of new halogenated compounds published in different journals (1994–2019).
Figure 9
Figure 9
Percentages of new halogenated compounds from different sources of marine origins (1994–2019).
Figure 10
Figure 10
Numbers of new halogenated compounds from different marine fungi (1994–2019).
Figure 11
Figure 11
Activity of new halogenated compounds from marine fungi (1994–2019).
Figure 12
Figure 12
Structural classes of new halogenated compounds (1994–2019).
Figure 13
Figure 13
Proportion of new halogenated compounds (1994–2019).
See this image and copyright information in PMC

References

    1. Zhao C., Zhu T., Zhu W. New marine natural products of microbial origin from 2010 to 2013. Chin. J. Org. Chem. 2013;33:1195–1234. doi: 10.6023/cjoc201304039. - DOI
    1. Butler A., Sandy M. Mechanistic considerations of halogenating enzymes. Nature. 2009;460:848–854. doi: 10.1038/nature08303. - DOI - PubMed
    1. Ballschmiter K. Review: Pattern and sources of naturally produced organohalogens in the marine environment: Biogenic formation of organohalogens. Chemosphere. 2003;52:313–324. doi: 10.1016/S0045-6535(03)00211-X. - DOI - PubMed
    1. Gribble G.-W. The diversity of naturally produced organohalogens. Chemosphere. 2003;52:289–297. doi: 10.1016/S0045-6535(03)00207-8. - DOI - PubMed
    1. Wang C.-Y., Hao J.-D., Ning X.-Y., Wu J.-S., Zhao D.-L., Kong C.-J., Shao C.-L., Wang C.-Y. Penicilazaphilones D and E: Two new azaphilones from a sponge-derived strain of the fungus Penicillium sclerotiorum. RSC Adv. 2018;8:4348–4353. doi: 10.1039/C7RA13327H. - DOI

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