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Review
. 2021 Jan 15;22(2):813.
doi: 10.3390/ijms22020813.

Osteosarcoma Pathogenesis Leads the Way to New Target Treatments

Isabel Fernandes  1   2 , Cecília Melo-Alvim  1 , Raquel Lopes-Brás  1 , Miguel Esperança-Martins  1   2   3 , Luís Costa  1   2
Affiliations
Review

Osteosarcoma Pathogenesis Leads the Way to New Target Treatments

Isabel Fernandes et al. Int J Mol Sci. .

Abstract

Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic research has enabled a better understanding of OS pathogenesis and the discovery of new potential therapeutic targets. Phase I and II clinical trials are already ongoing, with some promising results for these patients. This article reviews OS pathogenesis and new potential therapeutic targets.

Keywords: molecular targets; osteosarcoma; pathogenesis.

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Conflict of interest statement

Isabel Fernandes and Miguel Esperança-Martins—PharmaMar funding for research.

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