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Review
. 2021 Jan 15;11(1):60.
doi: 10.3390/life11010060.

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Carmine Izzo  1 , Paolo Vitillo  1 , Paola Di Pietro  1 , Valeria Visco  1 , Andrea Strianese  1 , Nicola Virtuoso  1 , Michele Ciccarelli  1 , Gennaro Galasso  1 , Albino Carrizzo  1   2 , Carmine Vecchione  1   2
Affiliations
Review

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Carmine Izzo et al. Life (Basel). .

Abstract

Aging can be seen as process characterized by accumulation of oxidative stress induced damage. Oxidative stress derives from different endogenous and exogenous processes, all of which ultimately lead to progressive loss in tissue and organ structure and functions. The oxidative stress theory of aging expresses itself in age-related diseases. Aging is in fact a primary risk factor for many diseases and in particular for cardiovascular diseases and its derived morbidity and mortality. Here we highlight the role of oxidative stress in age-related cardiovascular aging and diseases. We take into consideration the molecular mechanisms, the structural and functional alterations, and the diseases accompanied to the cardiovascular aging process.

Keywords: aging; cardiovascular diseases; molecular mechanisms; oxidative stress.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The impact of oxidative stress on age-associated heart diseases.
Figure 2
Figure 2
The impact of oxidative stress on age-associated vascular diseases.
See this image and copyright information in PMC

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