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Multicenter Study
. 2021 Jan 15;13(1):112.
doi: 10.3390/v13010112.

Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women

Monica Cruz-Lemini  1 , Elena Ferriols Perez  2 , Maria Luisa de la Cruz Conty  3 , Africa Caño Aguilar  4 , Maria Begoña Encinas Pardilla  5 , Pilar Prats Rodríguez  6 , Marta Muner Hernando  7 , Laura Forcen Acebal  8 , Pilar Pintado Recarte  9 , Maria Del Carmen Medina Mallen  1 , Noelia Perez Perez  10 , Judit Canet Rodriguez  11 , Ana Villalba Yarza  12 , Olga Nieto Velasco  13 , Pablo Guillermo Del Barrio Fernandez  14 , Carmen Maria Orizales Lago  15 , Beatriz Marcos Puig  16 , Begoña Muñoz Abellana  17 , Laura Fuentes Ricoy  18 , Agueda Rodriguez Vicente  19 , Maria Jesus Janeiro Freire  20 , Macarena Alferez Alvarez-Mallo  21 , Cristina Casanova Pedraz  22 , Onofre Alomar Mateu  23 , Cristina Lesmes Heredia  24 , Juan Carlos Wizner de Alva  25 , Alma Posadas San Juan  26 , Montserrat Macia Badia  27 , Cristina Alvarez Colomo  28 , Antonio Sanchez Muñoz  29 , Laia Pratcorona Alicart  30 , Ruben Alonso Saiz  31 , Monica Lopez Rodriguez  32 , Maria Carmen Barbancho Lopez  33 , Marta Ruth Meca Casbas  34 , Oscar Vaquerizo Ruiz  35 , Eva Moran Antolin  36 , Maria Jose Nuñez Valera  37 , Camino Fernandez Fernandez  38 , Albert Tubau Navarra  39 , Alejandra Maria Cano Garcia  40 , Susana Soldevilla Perez  41 , Irene Gattaca Abasolo  42 , Jose Adanez Garcia  43 , Alberto Puertas Prieto  44 , Rosa Ostos Serna  45 , Maria Del Pilar Guadix Martin  46 , Monica Catalina Coello  47 , Silvia Espuelas Malon  2 , Jose Antonio Sainz Bueno  48 , Maria Reyes Granell Escobar  49 , Sara Cruz Melguizo  5 , Oscar Martinez Perez  5 , On Behalf Of The Spanish Obstetric Emergency Group
Affiliations
Multicenter Study

Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women

Monica Cruz-Lemini et al. Viruses. .

Abstract

Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.

Keywords: SARS-CoV-2; asymptomatic infection; coronavirus; delivery; maternal complications; perinatal outcomes; pregnancy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the study data. PCR, polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

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