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Meta-Analysis
. 2021 Jan 19;19(1):17.
doi: 10.1186/s12957-021-02126-4.

Comparison of the overall survival of proximal and distal gastric cancer after gastrectomy: a systematic review and meta-analysis

Jiaming Xue #  1   2 , Huiliang Yang #  1   2 , Shanshan Huang #  2   3 , Tingting Zhou  3 , Xiangwen Zhang  4 , Guo Zu  5
Affiliations
Meta-Analysis

Comparison of the overall survival of proximal and distal gastric cancer after gastrectomy: a systematic review and meta-analysis

Jiaming Xue et al. World J Surg Oncol. .

Abstract

Background: The aim of this study was to investigate the overall survival (OS) between proximal gastric cancer (PG) and distal gastric cancer (DG) patients after gastrectomy.

Methods: Articles on the prognostic study of PG and DG patients after gastrectomy were collected from the PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases from the date of establishment until December 2020. The data were statistically analyzed by Stata software (version 11.0, StataCorp).

Results: A total of 10 articles met the inclusion criteria. Meta-analysis showed that the 1-, 3- and 5-year OS rates of PG patients were significantly lower than those of DG patients (RR = 0.898, 95% CI: 0.825 to 0.977, P = 0.013; RR = 0.802, 95% CI: 0.708 to 0.909, P = 0.001; RR = 0.736, 95% CI: 0.642 to 0.844, P = 0.000). After subgroup analysis according to different countries, the combined RR values of were as follows: 1-year OS: eastern countries: RR = 0.966, 95% CI: 0.944 to 0.988, P = 0.003, western countries: RR = 0.687, 95% CI: 0.622 to 0.759, P = 0.000; 3-year OS: eastern countries: RR = 0.846, 95% CI: 0.771 to 0.929, P = 0.000, western countries: RR = 0.742, 95% CI: 0.399 to 1.382, P = 0.348; and 5-year OS: eastern countries: RR = 0.798, 95% CI: 0.716 to 0.889, P = 0.000, western countries: RR = 0.646, 95% CI: 0.414 to 1.008, P = 0.054.

Conclusion: In terms of 1-, 3-, and 5-year OS, PG patients had lower rates than DG patients and the eastern countries/western countries subgroup, but there were no significant differences in 3- and 5-year OS for the western countries. These results merit further clinical validation in future studies. (Registration ID: UMIN000040393; Date of registration: 2020/05/13).

Keywords: Distal gastric cancer; Gastric cancer; Meta-analysis; Prognosis; Proximal gastric cancer.

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Conflict of interest statement

The authors declare that they have competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of the identification process for eligible studies
Fig. 2
Fig. 2
Forest graph of OS between PG and DG patients. a 1-year OS. b 3-year OS. c 5-year OS
Fig. 3
Fig. 3
Results of subgroup analysis of 1-year (a), 3-year (b), and 5-year OS (c) (group 1: eastern countries; group 2: western countries)
Fig. 4
Fig. 4
Begg’s test and Egger’s test of 1-year, 3-year, and 5-year OS. a 1-year OS. b 3-year OS. c 5-year OS
Fig. 5
Fig. 5
Sensitivity analysis of the overall pooled study. a 1-year OS. b 3-year OS. c 5-year OS
See this image and copyright information in PMC

References

    1. Song Z, Wu Y, Yang J, Yang D, Fang X. Progress in the treatment of advanced gastric cancer. Tumour Biol. 2017;39(7):1010428317714626. doi: 10.1177/1010428317714626. - DOI - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. doi: 10.3322/caac.21262. - DOI - PubMed
    1. Correa P. Gastric cancer: overview. Gastroenterol Clin North Am. 2013;42(2):211–217. doi: 10.1016/j.gtc.2013.01.002. - DOI - PMC - PubMed
    1. Yu X, Hu F, Li C, Yao Q, Zhang H, Xue Y. Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer. Onco Targets Ther. 2018;11:1037–1044. doi: 10.2147/OTT.S157378. - DOI - PMC - PubMed