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. 2021 Jan 19;22(1):64.
doi: 10.1186/s13063-020-05002-w.

In silico imaging clinical trials: cheaper, faster, better, safer, and more scalable

Aldo Badano  1
Affiliations

In silico imaging clinical trials: cheaper, faster, better, safer, and more scalable

Aldo Badano. Trials. .

Abstract

Imaging clinical trials can be burdensome and often delay patient access to novel, high-quality medical devices. Tools for in silico imaging trials have significantly improved in sophistication and availability. Here, I describe some of the principal advantages of in silico imaging trials and enumerate five lessons learned during the design and execution of the first all-in silico virtual imaging clinical trial for regulatory evaluation (the VICTRE study).

Keywords: Computational modeling; In silico trials; Regulatory evaluation.

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Conflict of interest statement

The author declares that he has no competing interests.

Figures

Fig. 1
Fig. 1
Example image regions containing a lesion. (from left to right) A spiculated mass shown embedded in the same location of a digital breast model seen in a DM and DBT image. The absorption of the lesion has been increased to ensure conspicuity for this illustration. A microcalcification cluster embedded in the same location of a digital breast model seen in a DM and DBT image. The DBT images correspond to a slice of the three-dimensional volume obtained from reconstructing the multiple angular projections
See this image and copyright information in PMC

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