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Comment
. 2021 Mar 17;89(4):e00001-21.
doi: 10.1128/IAI.00001-21. Print 2021 Mar 17.

The Benefits of Exporting: Engineered Extracellular Vesicles as Promising Vaccine Candidates against Enteric Fever

Marcio L Rodrigues  1   2
Affiliations
Comment

The Benefits of Exporting: Engineered Extracellular Vesicles as Promising Vaccine Candidates against Enteric Fever

Marcio L Rodrigues. Infect Immun. .

Abstract

The immunological potential of extracellular vesicles produced by Gram-negative bacteria, the so-called outer-membrane vesicles (OMVs), can be improved by genetic engineering, resulting in vesicles containing multiple immunogens. The potential of this approach for the development of a vaccine candidate for enteric fever was recently demonstrated by G. Gasperini, R. Alfini, V. Arato, F. Mancini, et al. (Infect Immun 89:e00699-20, 2021, https://doi.org/10.1128/IAI.00699-20). This commentary will discuss the use of OMVs to generate vaccines for enteric fever and the promise of this approach for prevention of other infectious diseases.

Keywords: enteric fever; extracellular vesicles; outer membrane vesicles; vaccines.

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