Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan 12:16:119-127.
doi: 10.2147/CIA.S288164. eCollection 2021.

Relationship Between Physical Performance and Mild Cognitive Impairment in Chinese Community-Dwelling Older Adults

Yuewen Liu #  1 , Weibo Ma #  2 , Ming Li  3 , Peipei Han  1 , Ming Cai  1 , Feng Wang  2 , Jingru Wang  2 , Xiaoyu Chen  1 , Jianrong Shi  4 , Xiaoyan Zhang  4 , Yiyi Zheng  1 , Mengqiu Chen  1 , Qi Guo  1 , Ying Yu  1
Affiliations

Relationship Between Physical Performance and Mild Cognitive Impairment in Chinese Community-Dwelling Older Adults

Yuewen Liu et al. Clin Interv Aging. .

Abstract

Objective: This study aimed to examine the relationship between physical performance and mild cognitive impairment (MCI) in Chinese older adults.

Methods: The sample comprised 956 relatively healthy and aged ≥65 years old Chinese community-dwelling participants (mean age, 72.56 ± 5.43 years; 56.8% female), which did not include those with dementia, severe cognitive impairment, mental illness etc. The Mini-Mental State Examination (MMSE) and the Instrumental Activities of Daily Living (IADL) scale were used for the initial classification of patients with MCI. Physical performance was measured via hand grip, Timed Up and Go Test (TUGT), and 4-m walking speed.

Results: The physical performance (grip strength, TUGT, and 4-m walking speed) correlated with MCI. The grip strength [odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.93-0.99] and 4-m walking speed (OR = 0.25, 95% CI = 0.10-0.64) correlated negatively with MCI, while TUGT (OR = 1.08, 95% CI = 1.03-1.13) and MCI correlated positively.

Conclusion: The physical performance (grip strength, TUGT, and 4-m walking speed) correlated with MCI. Further analysis showed that the grip strength was associated with overall cognition, time orientation, recall, and language, while TUGT and 4-m walking speed were associated with overall cognition and various cognitive domains, except recall.

Keywords: 4-meter walking speed; TUGT; grip strength; mild cognitive impairment.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest for this work.

References

    1. Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment–beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 2004;256(3):240–246. doi: 10.1111/j.1365-2796.2004.01380.x - DOI - PubMed
    1. Lopez ME, Turrero A, Cuesta P, et al. Searching for primary predictors of conversion from mild cognitive impairment to alzheimer’s disease: a multivariate Follow-Up study. J Alzheimers Dis. 2016;52(1):133–143. doi: 10.3233/JAD-151034 - DOI - PubMed
    1. Eshkoor SA, Hamid TA, Mun CY, et al. Mild cognitive impairment and its management in older people. Clin Interv Aging. 2015;10:687–693. doi: 10.2147/CIA.S73922 - DOI - PMC - PubMed
    1. Hebert LE, Scherr PA, Bienias JL, et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. 2003;60(8):1119–1122. doi: 10.1001/archneur.60.8.1119 - DOI - PubMed
    1. Montero-Odasso M, Oteng-Amoako A, Speechley M, et al. The motor signature of mild cognitive impairment: results from the gait and brain study. J Gerontol a Biol Sci Med Sci. 2014;69(11):1415–1421. doi: 10.1093/gerona/glu155 - DOI - PMC - PubMed