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Case Reports
. 2021 Jan 12;2021(1):omaa121.
doi: 10.1093/omcr/omaa121. eCollection 2021 Jan.

Gorham Stout disease: a case report from Syria

Asil Esper  1 , Sami Alhoulaiby  2 , Areege Emran  3 , Safwan Youssef  4 , Zuheir Alshehabi  5
Affiliations
Case Reports

Gorham Stout disease: a case report from Syria

Asil Esper et al. Oxf Med Case Reports. .

Abstract

Gorham-Stout disease (GSD) is a rare entity that destroys the bone matrix resulting mainly in osteolysis, pain and pathologic fractures among a broader clinical picture. We report a case of a 60-year-old female with a sudden discovery of pathologic fractures in the pelvis and the absence of the left femoral head. On biopsy, no cellular atypia was found, instead disturbed bone formation with prominent vascularity with scattered foci of necrosis & osteolysis, which lead to the diagnosis of GSD. Possible differential diagnoses were discussed and excluded. The patient was put on Bisphosphonate that led to a relative improvement in the symptoms. This disease needs a more thorough investigation to identify the key cause, what is beyond the scope of this report.

Keywords: Gorham Stout disease; angiomatosis; lytic bone disease; osteolysis; vanishing bone disease.

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Figures

Figure 1
Figure 1
Pelvic X-ray showing the detachment of the right pelvis with a clockwise rotation of the coronal plane.
Figure 2
Figure 2
Pelvic 3D-constructed CT: (A) anterior section. (B) Posterior section. Both sections show a complete absence of the left femoral head.
Figure 3
Figure 3
Pelvic MRI showing a complete absence of the left femoral head.
Figure 4
Figure 4
Microscopic photos (Hematoxylin and eosin stain ×100) showing scattered foci of necrosis & osteolysis (A), a replacement of bone by lobules of variable-sized vascular channels embedded in the cellular connective tissue (B), and proliferation of hemangioma-like blood vessels interspersed with broken trabeculae of lamellar bone (C) with no evidence of reactive bone formation.
Figure 5
Figure 5
CD 34 positive in proliferating blood vessel tissue—Angiomatosis.
See this image and copyright information in PMC

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