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[Preprint]. 2021 Jan 13:rs.3.rs-143532.
doi: 10.21203/rs.3.rs-143532/v1.

Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera

Pei-Yong Shi  1 , Xuping Xie  2 , Jing Zou  2 , Camila Fontes-Garfias  2 , Hongjie Xia  2 , Kena Swanson  3 , Mark Cutler  3 , David Cooper  3 , Vineet Menachery  4 , Scott Weaver  1 , Philip Dormitzer  5
Affiliations

Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera

Pei-Yong Shi et al. Res Sq. .

Update in

Abstract

Rapidly spreading variants of SARS-CoV-2 that have arisen in the United Kingdom and South Africa share the spike N501Y substitution, which is of particular concern because it is located in the viral receptor binding site for cell entry and increases binding to the receptor. We generated isogenic N501 and Y501 SARS-CoV-2. Twenty human sera from the mRNA-based vaccine BNT162b2 trial exhibited equivalent neutralizing titers to the N501 and Y501 viruses.

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Conflict of interest statement

Competing financial interests

X.X., V.D.M., and P.-Y.S. have filed a patent on the reverse genetic system. K.A.S., M.C., D.C., and P.R.D. are employees of Pfizer and may hold stock options. X.X., J.Z., C.R.F.G., H.X., and P.-Y.S. received compensation from Pfizer to perform the neutralization assay.

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