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Comparative Study
. 2021 Mar;28(3):659-664.
doi: 10.1007/s43032-020-00443-9. Epub 2021 Jan 19.

Protective Effects from the Ischemic/Hypoxic Stress Induced by Labor in the High-Altitude Tibetan Placenta

Wuren Tana  1   2 , Tenzing Noryung  3   4 , Graham J Burton  5 , Martha Tissot van Patot  6 , Ge Ri-Li  3   7
Affiliations
Comparative Study

Protective Effects from the Ischemic/Hypoxic Stress Induced by Labor in the High-Altitude Tibetan Placenta

Wuren Tana et al. Reprod Sci. 2021 Mar.

Abstract

Labor and vaginal delivery cause acute ischemic/hypoxic insult to the placenta. Previous studies demonstrate that placentas from high altitude non-natives showed blunted responses to ischemic/hypoxic insult caused by labor and vaginal birth, and there were some differences in the ATP/ADP production ratio. We hypothesized that adapted highlanders would not have a stress response to the acute hypoxia/ischemia of labor. Tibetan laboring (n = 10) and non-laboring (n = 5) and European descendants laboring (n = 10) and non-laboring (n = 5) high-altitude placentas were analyzed using genome-wide expression array analysis. There was no evidence for ischemic/hypoxic stress in high-altitude Tibetan laboring as compared with non-laboring placentas, while there were differences in gene expression between laboring and non-laboring placentas from high-altitude European descendants. Our results provide evidence for adaptation to acute hypoxic ischemic insult caused by labor and vaginal birth in placentas in a high-altitude native Tibetan population.

Keywords: High altitude; Labor; Placenta; Tibetan.

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References

    1. Brar HS, Platt LD, DeVore GR, Horenstein J, Medearis AL. Qualitative assessment of maternal uterine and fetal umbilical artery blood flow and resistance in laboring patients by Doppler velocimetry. Am J Obstet Gynecol. 1988;158(4):952–6. https://doi.org/10.1016/0002-9378(88)90100-7 . - DOI - PubMed
    1. Cindrova-Davies T, Yung HW, Johns J, Spasic-Boskovic O, Korolchuk S, Jauniaux E, et al. Oxidative stress, gene expression, and protein changes induced in the human placenta during labor. Am J Pathol. 2007;171(4):1168–79. https://doi.org/10.2353/ajpath.2007.070528 . - DOI - PubMed - PMC
    1. D'Angelo G, Granese R, Marseglia L, Impellizzeri P, Alibrandi A, Palmara A, et al. High mobility group box 1 and markers of oxidative stress in human cord blood. Pediatr Int. 2019;61(3):264–70. https://doi.org/10.1111/ped.13795 . - DOI - PubMed
    1. D'Angelo G, Marseglia L, Granese R, Di Benedetto A, Giacobbe A, Impellizzeri P, et al. Different concentration of human cord blood HMGB1 according to delivery and labour: a pilot study. Cytokine. 2018;108:53–6. https://doi.org/10.1016/j.cyto.2018.03.019 . - DOI - PubMed
    1. Stjernholm YV, Nyberg A, Cardell M, Hoybye C. Circulating maternal cortisol levels during vaginal delivery and elective cesarean section. Arch Gynecol Obstet. 2016;294(2):267–71. https://doi.org/10.1007/s00404-015-3981-x . - DOI - PubMed

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