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. 2021 Jan 20;16(1):e0245731.
doi: 10.1371/journal.pone.0245731. eCollection 2021.

Prevalence and sociodemographic correlates of anogenital Human Papillomavirus (HPV) carriage in a cross-sectional, multi-ethnic, community-based Asian male population

Su Pei Khoo  1 , Mohd Khairul Anwar Shafii  1 , Nirmala Bhoo-Pathy  1 , Siew Hwei Yap  1 , Shridevi Subramaniam  2 , Nazrila Hairizan Nasir  3 , Zhang Lin  4 , Jerome Belinson  5 , Pik Pin Goh  2 , Xinfeng Qu  5 , Patti Gravitt  6 , Yin Ling Woo  1
Affiliations

Prevalence and sociodemographic correlates of anogenital Human Papillomavirus (HPV) carriage in a cross-sectional, multi-ethnic, community-based Asian male population

Su Pei Khoo et al. PLoS One. .

Abstract

Background: Addressing the burden of HPV-associated diseases among men is increasingly becoming a public health issue. The main objective of this study was to determine HPV prevalence among a healthy community-based Malaysian men.

Method: This was a cross-sectional study that recruited 503 healthy males from 3 community-based clinics in Selangor, Malaysia. Genital and anal samples were collected from each participant for 14 high risk and 2 low risk HPV DNA detection and genotyping. All participants responded to a set of detailed sociodemographic and sexual behaviour questionnaire.

Results: The median age at enrolment was 40 years old (IQR: 31-50). The anogenital HPV6/11 prevalence was 3.2% whereas high risk HPV prevalence was 27.1%. The genital HPV prevalence for HPV6/11 was 2.9% while high risk HPV was 18.8%. HPV6/11 prevalence in the anal canal was 1.6% and high risk HPV was 12.7%. HPV 18 was the most prevalent genotype detected in the anogenital area. There was a significant independent association between genital and anal HPV infections.

Conclusion: Anogenital HPV infection is common among Malaysian men. These findings emphasize the ubiquity of HPV infection and thus the value of population-wide access to HPV prevention.

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Conflict of interest statement

YLW has received travel grants and honoraria for speaking and participating at meetings by Merck Sharp & Dohme, Copan, Cepheid and Roche. YLW has also received investigatorinitiated study grants from Roche, Merck and Cepheid. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. Sites of HPV infection distribution among HPV-positive subjects (n = 93).
See this image and copyright information in PMC

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