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Review
. 2021 Mar 1;106(3):664-670.
doi: 10.3324/haematol.2019.240747.

Maintenance therapy for FLT3-ITD-mutated acute myeloid leukemia

Andreas Burchert  1
Affiliations
Review

Maintenance therapy for FLT3-ITD-mutated acute myeloid leukemia

Andreas Burchert. Haematologica. .

Abstract

FLT3-ITD is a constitutively activated variant of the FLT3 tyrosine kinase receptor. Its expression in acute myeloid leukemia (AML) is associated with a poor prognosis. Due to this, the development of tyrosine kinase inhibitors (TKI) blocking FLT3-ITD became a rational therapeutic concept. This review describes key milestones in the clinical development of different FLT3-specific TKI with a particular focus on FLT3-TKI maintenance therapy in remission after allogeneic hematopoietic stem cell transplantation (HCT). Recent evidence from randomized trials using sorafenib in FLT3-ITD mutated AML provided a proof of concept that targeted post-HCT maintenance therapy could become a new treatment paradigm in AML.

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