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Case Reports
. 2021 Nov;22(7-8):595-598.
doi: 10.1080/21678421.2021.1876731. Epub 2021 Jan 21.

ALSUntangled 59: Tamoxifen

Richard Bedlack  1 , Sky Kihuwa-Mani  2 , Paul E Barkhaus  3 , Michael Bereman  4 , James B Caress  5 , Jesse Crayle  1 , Gary L Pattee  6 , Terry Heiman Patterson  7 , Paul Wicks  8 , Neta Zach  9 , Gregory T Carter  10 , Kristiana Salmon  11
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Case Reports

ALSUntangled 59: Tamoxifen

Richard Bedlack et al. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Nov.

Abstract

Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial.

Keywords: ALSUntangled; Tamoxifen; clinical trials; ethics; off-label treatment; therapy; trials.

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