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Multicenter Study
. 2021 Nov;93(11):6393-6397.
doi: 10.1002/jmv.26815. Epub 2021 Feb 1.

Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia

Angelica Rico  1 , Sheila C Dollard  2 , Diana Valencia  3 , Sheryll Corchuelo  1 , Van T Tong  3 , Katherine Laiton-Donato  1 , Minal M Amin  2 , Monica Benavides  4 , Phili Wong  2 , Suzanne Newton  5 , Marcela Daza  4 , Jordan Cates  3 , Maritza Gonzalez  1 , Laura D Zambrano  3 , Marcela M Mercado  1 , Elizabeth C Ailes  3 , Helena M Rodriguez  1 , Suzanne M Gilboa  3 , Jacqueline Acosta  4 , Jessica Ricaldi  3 , Dioselina Pelaez  1 , Margaret A Honein  3 , Martha L Ospina  1 , Tatiana M Lanzieri  2
Affiliations
Multicenter Study

Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia

Angelica Rico et al. J Med Virol. 2021 Nov.

Abstract

We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%-98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%-18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%-59.1%) had postnatal infection.

Keywords: CMV; Colombia; congenital infection; cytomegalovirus; newborns; postnatal infection; prevalence; seroprevalence.

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Conflict of interest statement

CONFLICT OF INTERESTS

The authors declare that there are no conflict of interests.

Figures

FIGURE 1
FIGURE 1
Cytomegalovirus (CMV) testing, congenital and postnatal infection among infants enrolled in the ZEN study
See this image and copyright information in PMC

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