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Multicenter Study
. 2021 Nov;93(11):6393-6397.
doi: 10.1002/jmv.26815. Epub 2021 Feb 1.

Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia

Angelica Rico  1 , Sheila C Dollard  2 , Diana Valencia  3 , Sheryll Corchuelo  1 , Van T Tong  3 , Katherine Laiton-Donato  1 , Minal M Amin  2 , Monica Benavides  4 , Phili Wong  2 , Suzanne Newton  5 , Marcela Daza  4 , Jordan Cates  3 , Maritza Gonzalez  1 , Laura D Zambrano  3 , Marcela M Mercado  1 , Elizabeth C Ailes  3 , Helena M Rodriguez  1 , Suzanne M Gilboa  3 , Jacqueline Acosta  4 , Jessica Ricaldi  3 , Dioselina Pelaez  1 , Margaret A Honein  3 , Martha L Ospina  1 , Tatiana M Lanzieri  2
Affiliations
Multicenter Study

Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia

Angelica Rico et al. J Med Virol. 2021 Nov.

Abstract

We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%-98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%-18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%-59.1%) had postnatal infection.

Keywords: CMV; Colombia; congenital infection; cytomegalovirus; newborns; postnatal infection; prevalence; seroprevalence.

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Conflict of interest statement

CONFLICT OF INTERESTS

The authors declare that there are no conflict of interests.

Figures

FIGURE 1
FIGURE 1
Cytomegalovirus (CMV) testing, congenital and postnatal infection among infants enrolled in the ZEN study
See this image and copyright information in PMC

References

    1. Rawlinson WD, Boppana SB, Fowler KB, et al. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis. 2017;17(6):e177–e188. - PubMed
    1. Britt W Infectious diseases of the fetus and newborn 7th edition, Elsevier Inc. 2011;706–755. 10.1016/B978-1-4160-6400-8.00023-7 - DOI
    1. Lanzieri TM, Dollard SC, Bialek SR, Grosse SD. Systematic review of the birth prevalence of congenital cytomegalovirus infection in developing countries. Int J Infect Dis. 2014;22:44–48. - PMC - PubMed
    1. Rasanathan JJ, MacCarthy S, Diniz D, Torreele E, Gruskin S. Engaging human rights in the response to the evolving Zika virus epidemic. Am J Public Health. 2017;107(4):525–531. - PMC - PubMed
    1. Gonzalez M, Tong V, Rodriguez H, et al. Cohort profile: congenital Zika virus infection and child neurodevelopmental outcomes; Zika en embarazadas y ninos (ZEN) cohort study in Colombia. Epidemiol Health. 2020:e2020060. - PMC - PubMed

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