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Meta-Analysis
. 2021 Nov;51(11):4101-4114.
doi: 10.1007/s10803-020-04839-z. Epub 2021 Jan 21.

Systematic Review and Meta-Analysis of the Clinical Utility of the ADOS-2 and the ADI-R in Diagnosing Autism Spectrum Disorders in Children

Jenna B Lebersfeld  1 , Marissa Swanson  2 , Christian D Clesi  2 , Sarah E O'Kelley  2
Affiliations
Meta-Analysis

Systematic Review and Meta-Analysis of the Clinical Utility of the ADOS-2 and the ADI-R in Diagnosing Autism Spectrum Disorders in Children

Jenna B Lebersfeld et al. J Autism Dev Disord. 2021 Nov.

Abstract

The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) and the Autism Diagnostic Interview, Revised (ADI-R) have high accuracy as diagnostic instruments in research settings, while evidence of accuracy in clinical settings is less robust. This meta-analysis focused on efficacy of these measures in research versus clinical settings. Articles (n = 22) were analyzed using a hierarchical summary receiver operating characteristics (HSROC) model. ADOS-2 performance was stronger than the ADI-R. ADOS-2 sensitivity and specificity ranged from .89-.92 and .81-.85, respectively. ADOS-2 accuracy in research compared with clinical settings was mixed. ADI-R sensitivity and specificity were .75 and .82, respectively, with higher specificity in research samples (Research = .85, Clinical = .72). A small number of clinical studies were identified, indicating ongoing need for investigation outside research settings.

Keywords: ADI-R; ADOS-2; Autism spectrum disorder; Diagnosis; HSROC; Meta-analysis.

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References

    1. Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
    1. American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders (4th ed., Text Revision). Washington, DC: Author.
    1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: Author. - DOI
    1. Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., & Charman, T. (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet, 368, 210–15. - DOI
    1. Camodeca, A. (2018). Utility of three N-Item scales of the child behavior checklist 6–18 in autism diagnosis. Research in Autism Spectrum Disorder, 51, 75–85. https://doi.org/10.1016/j.rasd.2018.04.004 . - DOI