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Review
. 2021 Jan 19;22(2):959.
doi: 10.3390/ijms22020959.

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Ruihong Zheng  1 , Shoujie Li  1 , Xuan Zhang  1 , Changqi Zhao  1
Affiliations
Review

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Ruihong Zheng et al. Int J Mol Sci. .

Abstract

Secondary metabolites isolated from plant endophytic fungi have been getting more and more attention. Some secondary metabolites exhibit high biological activities, hence, they have potential to be used for promising lead compounds in drug discovery. In this review, a total of 134 journal articles (from 2017 to 2019) were reviewed and the chemical structures of 449 new metabolites, including polyketides, terpenoids, steroids and so on, were summarized. Besides, various biological activities and structure-activity relationship of some compounds were aslo described.

Keywords: biological activity; endophytic fungi; new secondary metabolites; structural feature.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Percentage of metabolites synthesized by endophytes.
Figure 2
Figure 2
Chemical structures of sesquiterpenoids and derivatives.
Figure 2
Figure 2
Chemical structures of sesquiterpenoids and derivatives.
Figure 2
Figure 2
Chemical structures of sesquiterpenoids and derivatives.
Figure 3
Figure 3
Chemical structures of diterpenoids and derivatives.
Figure 4
Figure 4
Chemical structures of other terpenoids and derivatives.
Figure 4
Figure 4
Chemical structures of other terpenoids and derivatives.
Figure 5
Figure 5
Chemical structures of polyketides.
Figure 5
Figure 5
Chemical structures of polyketides.
Figure 6
Figure 6
Chemical structures of other ketones.
Figure 7
Figure 7
Chemical structures of alkaloids and their derivatives.
Figure 8
Figure 8
Chemical structures of penylpropanoids and their derivatives.
Figure 9
Figure 9
Chemical structures of lactones.
Figure 9
Figure 9
Chemical structures of lactones.
Figure 10
Figure 10
Chemical structures of anthraquinones.
Figure 10
Figure 10
Chemical structures of anthraquinones.
Figure 11
Figure 11
Chemical structures of sterides.
Figure 12
Figure 12
Chemical structures of other new compounds.
Figure 12
Figure 12
Chemical structures of other new compounds.
Figure 12
Figure 12
Chemical structures of other new compounds.
Figure 12
Figure 12
Chemical structures of other new compounds.
Figure 12
Figure 12
Chemical structures of other new compounds.
Figure 13
Figure 13
Chemical structures of known compounds.
See this image and copyright information in PMC

References

    1. Elshafie H., Viggiani L., Mostafa M.S., El-Hashash M.A., Camele I., Bufo S.A. Biological activity and chemical identification of ornithine lipid produced by Burkholderia gladioli pv. agaricicola ICMP 11096 using LC-MS and NMR analyses. J. Biol. Res.—Bollettino della Società Italiana di Biologia Sperimentale. 2018;90:96–103. doi: 10.4081/jbr.2017.6534. - DOI
    1. Camele I., Elshafie H.S., Caputo L., Sakr S.H., De Feo V. Bacillus mojavensis: Biofilm formation and biochemical investigation of its bioactive metabolites. J. Biol. Res.—Bollettino della Società Italiana di Biologia Sperimentale. 2019;92:39–45. doi: 10.4081/jbr.2019.8296. - DOI
    1. Kong D.W., Niu R.C., Mao Y.Z., Liu L.L. Research progress on active metabolites of endophytes. Keshan Branch Heilongjiang Acad. Agric. Sci. 2019;12:151–154.
    1. Ding W.J., Wang S.S., Ren J.Q., Li G., Zhan J.P. Progress on plant endophyte. Curr. Biotechnol. 2015;5:425–428.
    1. J in J., Zhao Q., Zhang X.M., Li W.J. Research progress on bioactive products from endophytes. J. Microbiol. 2018;38:103–113.

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