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Review
. 2021 Jan 21;21(1):66.
doi: 10.1186/s12935-021-01773-7.

Anti-tumor activity of resveratrol against gastric cancer: a review of recent advances with an emphasis on molecular pathways

Milad Ashrafizadeh  1   2 , Hossein Rafiei  3 , Reza Mohammadinejad  4 , Tahereh Farkhondeh  5   6 , Saeed Samarghandian  7
Affiliations
Review

Anti-tumor activity of resveratrol against gastric cancer: a review of recent advances with an emphasis on molecular pathways

Milad Ashrafizadeh et al. Cancer Cell Int. .

Abstract

Gastric cancer (GC) is one of the most common cancers with high malignancy. In spite of the great development in diagnostic tools and application of anti-tumor drugs, we have not witnessed a significant increase in the survival time of patients with GC. Multiple studies have revealed that Wnt, Nrf2, MAPK, and PI3K/Akt signaling pathways are involved in GC invasion. Besides, long non-coding RNAs and microRNAs function as upstream mediators in GC malignancy. GC cells have acquired resistance to currently applied anti-tumor drugs. Besides, combination therapy is associated with higher anti-tumor activity. Resveratrol (Res) is a non-flavonoid polyphenol with high anti-tumor activity used in treatment of various cancers. A number of studies have demonstrated the potential of Res in regulation of molecular pathways involved in cancer malignancy. At the present review, we show that Res targets a variety of signaling pathways to induce apoptotic cell death and simultaneously, to inhibit the migration and metastasis of GC cells.

Keywords: Anti‐tumor activity; Cancer prevention; Cell signaling; Gastric cancer; Molecular pathways; Resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Application of Res in GC therapy. Hh hedgehog, GC gastric cancer, PI3K phosphatidylinositide 3-kinase
See this image and copyright information in PMC

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