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. 1977 Dec;60(6):1442-4.
doi: 10.1172/JCI108906.

Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis

P Arnaud, R M Galbraith, W P Faulk

Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis

P Arnaud et al. J Clin Invest. 1977 Dec.

Abstract

Pi phenotypes of alpha-1-protease inhibitor were determined by isoelectric focusing and print immunofixation in 96 English children suffering from juvenile chronic polyarthritis. A significantly increased frequency of the MZ phenotype (10.41%) was found in comparison with a geographically matched control population (1.6%). The results of this study suggest that the possession of a Z-deficient allele of alpha-1-protease inhibitor could be a predisposing, aggravating, or perpetuating factor in the articular damage occurring in juvenile chronic polyarthritis.

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