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Editorial
. 2021 Jan;23(1):136-139.
doi: 10.1002/ejhf.2106. Epub 2021 Feb 3.

OUTSTEP-HF: re-evaluating the role of physical activity measures in drug and device development in heart failure

Kieran F Docherty  1 , Muthiah Vaduganathan  2
Affiliations
Free article
Editorial

OUTSTEP-HF: re-evaluating the role of physical activity measures in drug and device development in heart failure

Kieran F Docherty et al. Eur J Heart Fail. 2021 Jan.
Free article
No abstract available

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References

    1. Barker J, Smith Byrne K, Doherty A, Foster C, Rahimi K, Ramakrishnan R, Woodward M, Dwyer T. Physical activity of UK adults with chronic disease: cross-sectional analysis of accelerometer-measured physical activity in 96 706 UK Biobank participants. Int J Epidemiol 2019;48:1167-1174.
    1. Young DR, Reynolds K, Sidell M, Brar S, Ghai NR, Sternfeld B, Jacobsen SJ, Slezak JM, Caan B, Quinn VP. Effects of physical activity and sedentary time on the risk of heart failure. Circ Heart Fail 2014;7:21-27.
    1. Ferreira JP, Duarte K, Graves TL, Zile MR, Abraham WT, Weaver FA, Lindenfeld J, Zannad F. Natriuretic peptides, 6-min walk test, and quality-of-life questionnaires as clinically meaningful endpoints in HF trials. J Am Coll Cardiol 2016;68:2690-2707.
    1. U.S. Food and Drug Administration. Treatment for Heart Failure: Endpoints for Drug Development Guidance for Industry Draft Guidance. June 2019. https://www.fda.gov/regulatory-information/search-fda-guidance-documents... (10 January 2021).
    1. Edelmann F, Jaarsma T, Comin-Colet J, Schorr J, Ecochard L, Hussain RI, Piepoli MF. Rationale and study design of OUTSTEP-HF: a randomised controlled study to assess the effect of sacubitril/valsartan and enalapril on physical activity measured by accelerometry in patients with heart failure with reduced ejection fraction. Eur J Heart Fail 2020;22:1724-1733.

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