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Review
. 2021 Jun;58(6):2634-2642.
doi: 10.1007/s12035-020-02240-6. Epub 2021 Jan 22.

SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation

Kouminin Kanwore  1 , Xiao-Xiao Guo  1 , Ayanlaja Abiola Abdulrahman  1 , Piniel Alphayo Kambey  1 , Iqra Nadeem  1 , Dianshuai Gao  2
Affiliations
Review

SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation

Kouminin Kanwore et al. Mol Neurobiol. 2021 Jun.

Abstract

Failed neuroprotection leads to the initiation of several diseases. SOX1 plays many roles in embryogenesis, oncogenesis, and male sex determination, and can promote glioma stem cell proliferation, invasion, and migration due to its high expression in glioblastoma cells. The functional versatility of the SOX1 gene in malignancy, epilepsy, and Parkinson's disease, as well as its adverse effects on dopaminergic neurons, makes it an interesting research focus. Hence, we collate the most important discoveries relating to the neuroprotective effects of SOX1 in brain cancer and propose hypothesis worthy of SOX1's role in the survival of senescent neuronal cells, its roles in fibroblast cell proliferation, and cell fat for neuroprotection, and the discharge of electrical impulses for homeostasis. Increase in electrical impulses transmitted by senescent cells affects the synthesis of neurotransmitters, which will modify the brain cell metabolism and microenvironment.

Keywords: Ectoderm; Embryogenesis; Glioblastoma; Neuroprotection; SOX1; TGF-β.

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