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Case Reports
. 2021 May 1;43(5):373-376.
doi: 10.1097/DAD.0000000000001903.

Iatrogenic Arsenism Characterized by Palmoplantar Hyperkeratosis and Diffused Skin Cancers for Over Decades

Cui-Cui Tian  1 , Feng-Qiu Hu, Sha Lu, Guo-Zhen Tan, Liangchun Wang
Affiliations
Case Reports

Iatrogenic Arsenism Characterized by Palmoplantar Hyperkeratosis and Diffused Skin Cancers for Over Decades

Cui-Cui Tian et al. Am J Dermatopathol. .

Abstract

Chronic arsenism usually occurs after a long-term unawareness of arsenic exposure from environment, occupation, food, and water. We here reported 3 cases with diffused arsenic keratosis and skin cancers derived from long-term arsenic medication ingestion. In these cases, hyperkeratotic skin lesions were initially found on palms and soles, slowly progressed to every part of the skin and lasted maximally for over 30 years. Skin cancers were diagnosed and removed intermittently within decades, but with no malignancies in other organs. Oral retinoids combing with topical 5- fluorouracil and photodynamic treatment yielded a desirable outcome.

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Conflict of interest statement

The authors declare no conflicts of interest.

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