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Comment
. 2021 Jan 21;81(2):223-225.
doi: 10.1016/j.molcel.2020.12.043.

To Degrade a MicroRNA, Destroy Its Argonaute Protein

Pei-Hsuan Wu  1 , Phillip D Zamore  2
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To Degrade a MicroRNA, Destroy Its Argonaute Protein

Pei-Hsuan Wu et al. Mol Cell. .
Free article

Abstract

Han et al. (2020) and Shi et al. (2020) report that the E3 ubiquitin ligase ZSWIM8 senses when an RNA and an Argonaute protein-bound microRNA are extensively base paired and directs Argonaute destruction by the proteasome. The result is degradation of the microRNA.

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Conflict of interest statement

Declaration of Interests P.D.Z. is a member of the advisory board of Molecular Cell. P.D.Z. is an inventor on patents filed by the University of Massachusetts describing the use of highly complementary synthetic oligonucleotides to inhibit microRNA function in cells and in vivo.

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