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Comment
. 2021 Jan 21;184(2):294-296.
doi: 10.1016/j.cell.2020.12.035.

Basophils add fuel to the flame of eczema itch

Sonali S Mali  1 , Diana M Bautista  2
Affiliations
Comment

Basophils add fuel to the flame of eczema itch

Sonali S Mali et al. Cell. .

Abstract

Children and adults with atopic dermatitis suffer from intractable chronic itch and can also experience acute itch flare ups that significantly increase itch intensity. In this issue of Cell, Wang et al. demonstrate that a subset of basophils activates sensory neurons to drive allergen-evoked itch flare ups in atopic dermatitis.

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Conflict of interest statement

Declaration of interests D.M.B. is on the scientific advisory board of eScient Pharmaceuticals. She has patents pending on inhibiting neuronal signaling to treat development of chronic itch.

Comment on

  • A basophil-neuronal axis promotes itch.
    Wang F, Trier AM, Li F, Kim S, Chen Z, Chai JN, Mack MR, Morrison SA, Hamilton JD, Baek J, Yang TB, Ver Heul AM, Xu AZ, Xie Z, Dong X, Kubo M, Hu H, Hsieh CS, Dong X, Liu Q, Margolis DJ, Ardeleanu M, Miller MJ, Kim BS. Wang F, et al. Cell. 2021 Jan 21;184(2):422-440.e17. doi: 10.1016/j.cell.2020.12.033. Epub 2021 Jan 14. Cell. 2021. PMID: 33450207 Free PMC article.

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