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Comment
. 2021 Jan 21;184(2):301-303.
doi: 10.1016/j.cell.2020.12.030.

"Structuromics": another step toward a holistic view of the cell

Emmanuel D Levy  1 , Christine Vogel  2
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Comment

"Structuromics": another step toward a holistic view of the cell

Emmanuel D Levy et al. Cell. .
Free article

Abstract

Large-scale mapping of protein structures and their different states is crucial for gaining a mechanistic understanding of proteome function and regulation. In this issue of Cell, Cappelletti et al. achieve such a feat and identify hundreds of protein structural changes in response to outside stressors, providing a rich "structuromics" resource characterizing cellular adaptation.

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  • Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ.
    Cappelletti V, Hauser T, Piazza I, Pepelnjak M, Malinovska L, Fuhrer T, Li Y, Dörig C, Boersema P, Gillet L, Grossbach J, Dugourd A, Saez-Rodriguez J, Beyer A, Zamboni N, Caflisch A, de Souza N, Picotti P. Cappelletti V, et al. Cell. 2021 Jan 21;184(2):545-559.e22. doi: 10.1016/j.cell.2020.12.021. Epub 2020 Dec 23. Cell. 2021. PMID: 33357446 Free PMC article.

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