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. 1988 Mar;42(3):516-20.

Glucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy

A M Ferraris  1 , G Broccia, T Meloni, G Forteleoni, G F Gaetani
Affiliations

Glucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy

A M Ferraris et al. Am J Hum Genet. 1988 Mar.

Abstract

We have evaluated the hypothesis of a negative association between glucose 6-phosphate dehydrogenase (G6PD) deficiency and cancer in a cohort of 481 Sardinian males with hematological malignancies. The frequency of G6PD deficiency in the patients was not different from the incidence in a group of 16,219 controls. The same conclusion resulted from the comparison of the frequency of expression of the GdB gene in 23 heterozygous women having a clonal hematologic disease and a control group of 37 healthy heterozygotes. Therefore at present there is no evidence that G6PD deficiency has a protective effect against development of hematologic neoplasms.

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