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Meta-Analysis
. 2021 Mar:159:103231.
doi: 10.1016/j.critrevonc.2021.103231. Epub 2021 Jan 19.

The relationship between hypoxia-inducible factor 1α (HIF-1α) and patient survival in breast cancer: Systematic review and meta-analysis

Suad A K Shamis  1 , Donald C McMillan  2 , Joanne Edwards  3
Affiliations
Free article
Meta-Analysis

The relationship between hypoxia-inducible factor 1α (HIF-1α) and patient survival in breast cancer: Systematic review and meta-analysis

Suad A K Shamis et al. Crit Rev Oncol Hematol. 2021 Mar.
Free article

Abstract

Introduction: Hypoxia is a characteristic of many solid tumours and results in an increase in expression of HIF-1α. Many studies have investigated the prognostic value of HIF-1α expression in breast cancer (BC), however, the prognostic value remains unclear. Therefore, a systematic review and meta-analysis was undertaken to determine the prognostic value of HIF-1α in BC patients.

Methods: The electronic databases PubMed and Web of science were systematically searched to identify relevant papers. The clinical outcomes included disease-free survival (DFS), recurrence-free survival (RFS) and overall survival (OS) in BC patients. Review Manager version 5.4 was employed to analysis data from 30 eligible studies (containing 6201patients).

Results: High expression of HIF-1α was associated with poorer DFS and OS. There was an effect of survival analysis, study region, antibodies used, scoring and threshold methods on HIF-1α expression.

Conclusion: HIF-1α overexpression was significantly associated with poorer DFS and OS in breast cancer patients.

Keywords: Breast cancer; Disease free survival; HIF-1 α; Meta-analysis; Overall survival; Systematic review.

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