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. 2021 Apr;19(2):169-171.
doi: 10.1016/j.gpb.2020.12.005. Epub 2021 Jan 19.

Single-cell RNA Sequencing Deciphers Immune Landscape of Human Recurrent Miscarriage

Chunyu Huang  1 , Yong Zeng  2 , Wenwei Tu  3
Affiliations

Single-cell RNA Sequencing Deciphers Immune Landscape of Human Recurrent Miscarriage

Chunyu Huang et al. Genomics Proteomics Bioinformatics. 2021 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Overactivation of immune status at maternal-fetal interface in RM/RPL patients The proportion of pro-inflammatory immune cell subsets (e.g., dNK3, dM1, peripheral CD8+ effector T, MAIT, and CD56dimCD16+ NK cells) is increased, whereas the proportion of anti-inflammatory immune cell subsets (e.g., dNK1, dNK2, dM2, peripheral CD4+ naïve T, CD8+ naïve T, CD4+ memory T, and CD56brightCD16− NK cells) is decreased in decidua and peripheral blood, together leading to overactivation of immune status at the maternal-fetal interface in RM/RPL patients. dM, decidual macrophage; dNK, decidual NK; EVT, extravillous trophoblast; GPF, growth-promoting factor; MAIT, mucosal-associated invariant T; RM, recurrent miscarriage; RPL, recurrent pregnancy loss.
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