Routine Screening for Sepsis in an Obstetric Population: Evaluation of an Improvement Project

Abstract

Introduction: Our objectives were to calculate the timeliness of treatment following implementation of routine sepsis screening in an inpatient obstetric population using obstetric-adjusted systemic inflammatory response syndrome (SIRS) criteria, evaluate the performance of obstetric-specific screening criteria in the identification of sepsis, and to better characterize the frequency of end-organ dysfunction associated with those who met the definition of sepsis.

Methods: Electronic medical record data were collected from all pregnant or newly delivered women admitted for observation, admission, or postpartum readmission in the hospital maternity unit from March 1 through December 31, 2017 (n = 5075). Combinations of SIRS criteria were collected and compared with clinical indicators of end-organ dysfunction in those who met the definition of sepsis. Maternal conditions and neonatal outcomes were evaluated.

Results: In the study period, 204 cases of sepsis were identified among 201 women, 2 of whom experienced multiple episodes of sepsis, resulting in an incidence of sepsis of 4.0 per 100 livebirths. There were 92 (45.2%) with sepsis and 112 (54.9%) with end-organ dysfunction. Two women were admitted to the intensive care unit and no women died from sepsis.

Discussion: Use of a standardized, obstetric-specific sepsis screening process provided for early identification and treatment of sepsis in this population. Fourteen unique combinations of SIRS criteria were noted among those with sepsis; no combination was uniquely associated with the severity of sepsis.

Conclusion: Pregnant and newly delivered women benefitted from implementation of routine sepsis screening; this resulted in timely initiation of treatment.