High-mechanical strength carboxymethyl chitosan-based hydrogel film for antibacterial wound dressing

Abstract

Hydrogels, being highly biocompatible and adaptable with biological tissues, have shown great usability in biomedical applications. In this research, a novel hydrogel film developed from carboxymethyl chitosan (CMCS) loaded with waterborne polyurethane-gelatin hydrolysate was synthesized via aqueous emulsion copolymerization. The synthesized hydrogel film was characterized using mechanical strength tests, FTIR, XPS, SEM, AFM, and various other analysis technologies. The results demonstrated that the hydrogel film exhibited good thermal stability, swelling behavior, as well as controllable biodegradability. Specifically, when the CMCS content was loaded at 6 %, the maximum tensile strength and elongation at the break of the hydrogel film were reached 31.69 MPa and 447.187, respectively. The disk diffusion tests indicated that the hydrogel film presented significant antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). These results indicate that hydrogel films with high mechanical strength and high antibacterial activity could be used for wound dressing applications.

Keywords: 1,4-Butanediol (Pubchem CID: 8064); 2,4-Toluene diisocyanate (Pubchem CID: 11443); Antibacterial hydrogel; Calcium chloride (Pubchem CID: 24844); Carboxymethyl chitosan; Carboxymethyl chitosan (Pubchem CID: 71306969); Dimethylolpropionic acid (Pubchem CID: 78501); Disodium hydrogen phosphate (Pubchem CID: 24203); Gelatin; Hydrochloric acid (Pubchem CID: 313); Polypropylene oxide glycol (Pubchem CID: 32881); Triethylamine (Pubchem CID: 8471); Trypsin (Pubchem CID: 5311489); Waterborne polyurethane.